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WEBINAR 1999-05-05 Peter Nelson, with Dennis Selkoe, John Hardy, and Alain Israel, led this live discussion on 5 May 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion with Dennis Selkoe,
RESEARCH NEWS 1999-05-03 Research News Evidence from several sources suggests that the dorsal hippocampus is critical for the formation and storage of spatial information. In the long term, such information is believed to be transferred to the neocortex for storage. While it is a
RESEARCH NEWS 1999-04-30 Research News The armadillo gene-so named because its mutated form in fruit flies produces a phenotype with short spiky hairs, reminiscent of those on the armadillo-codes for a protein that is a homologue of the human β-catenin. These proteins and other,
COMMENT Inflammation, free radicals, and cytokines are involved in a vascular cascade producing the transformation of macrophages into foam cells between the endothelial cell layer and the basement membrane of a blood vessel leading to formation of an atheroscler
RESEARCH NEWS 1999-04-28 Research News Atherosclerotic processes are drawing the attention of some Alzheimer's researchers who point to a number of links between atherosclerotic disease and Alzheimer's disease. It is only natural then, that vitamin E, a hot topic in the
COMMENT Reply by Steven Barger Regardless of whether presenilins really are γ-secretases (for which the data seem to tipping the scales), the data seem quite clear that they are somehow involved in proteolytic processing of both APP and Notch. To me, one of the m
COMMENT Reply by E. Preddie and J. Bergmann 1. Considering what was known before, the nature of the experiments done by Wolfe and colleagues and the results obtained, it appears that the conclusion expressed by 'Ye' et al from their results is equally v
COMMENT Reply to Ratan Bhat by Rudy Tanzi: The main problem with this hypothesis is that since the time of publication of the commentary by Tuck Finch and I in Science, we now know that PS2 does not bind β- or delta-catenin (Tesco et al., J. Biol Chem., 1998). Ye
COMMENT Question from Ratan Bhat There have been suggestions that an increase in beta-catenin could mask some the mutation sites within PS1 (Tanzi and Finch in their Science comment), thereby stabilizing PS1, decreasing γ-secretase activity and subsequently β amy
RESEARCH NEWS 1999-04-23 Research News At the American Academy of Neurology meeting in Toronto, Scott Small and colleagues presented data suggesting that fMRI can distinguish early AD-related memory decline from other sources of memory decline. Citing evidence that entorhinal cor
RESEARCH NEWS 1999-04-15 Research News In the search for the elusive γ-secretase that cleaves β-amyloid precursor protein (APP), much attention has been paid to the protein Notch, which is critical in developmental pathways and has recently been found to be important in immune fu
COMMENT Reply by Dennis Selkoe Dear John: In response to your News and Views in the 8 April issue of Nature, I thought it would be helpful to indicate several points about your comments regarding the role of presenilins in APP processing with which my colleagues
RESEARCH NEWS 1999-04-09 Research News Three-dimensional images of enzymes at work in cells? This is the promise of a new advance in microscopy called fluorescence lifetime imaging microscopy (FLIM). Philippe Bastiaens and Anthony Squire at the Imperial Cancer Research Fund in Lo
RESEARCH NEWS 1999-04-05 Research News Fred Van Leeuwen and his colleagues reported last year that some neurons in Alzheimer's patients contain mutant RNA coding for APP and ubiquitin, despite the fact that the DNA from which the RNA had been transcribed was not mutated. By
RESEARCH NEWS 1999-04-01 Research News β-catenin, a protein that regulates transcription, has drawn attention in Alzheimer's research because it interacts with PS1 and PS2. It was also recently found that AD patients with the PS1 mutation have markedly reduced β-catenin in t
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