343574 RESULTS
RESEARCH NEWS 1999-03-15 Research News The University of California, San Diego, Alzheimer's Disease Cooperative Study Center is launching a $22 million study to determine whether medical intervention in individuals with mild cognitive impairment (MCI), characterized primaril
RESEARCH NEWS 1999-02-26 Research News In the mid-1980s, Finnish researchers reported that 68 percent of heart attack patients and 50 percent of those with coronary heart disease had antibodies to the bacterium Chlamydia pneumoniae, as compared to 17 percent of healthy controls.
RESEARCH NEWS 1999-02-25 Research News Scientists at Sandia National Laboratories and M.I.T. have created the first computer simulation that successfully models how protein misfolding can occur. Protein misfolding is theorized to turn normally benign proteins into toxic aggregate
RESEARCH NEWS 1999-02-24 Research News Neurons are highly polarized cells, with certain proteins within them clearly restricted to specific regions of the plasma membrane. Yet they lack any obvious barriers to free protein diffusion that could explain this asymmetric distribution
RESEARCH NEWS 1999-02-22 Research News Several years ago, Karen Hsiao and colleagues at the University of Minnesota reported that mice containing an FAD mutant form of the human amyloid precursor protein (APP) are impaired in their ability to learn. These mice, however, do not ex
RESEARCH NEWS 1999-01-29 Research News The E4 gene variant of apolipoprotein E (ApoE) confers an increased risk of developing Alzheimer’s disease, but the mechanisms by which it does so are not understood. ApoE plays a role in transporting fatty molecules to cell membranes, and m
INTERVIEWS 1999-01-26 Interviews ARF: What’s the primary hypothesis that guides your lab group? RN: We’ve said for many years that we think that the carboxy terminal fragment of APP, that we call C100, which would result from cleavage at the N-terminus of the A-beta sequence,
INTERVIEWS 1999-01-18 Interviews ARF: What is the primary hypothesis that guides your laboratory? PC: The primary hypothesis that guides my laboratory shifts from time to time as we and other people get more data; but the primary hypothesis in the lab now is that a cell in AD
INTERVIEWS 1999-01-08 Interviews ARF: What is the primary hypothesis that drives your lab group? DS: The primary hypothesis is that a chronic imbalance in the production versus the clearance of Aβ leading to a gradual rise in its steady state levels in brain tissue is the caus
INTERVIEWS 1998-12-22 Interviews HP: One of the few things about Alzheimer's disease on which everyone basically agrees is that it starts 20 or 30 years before the first symptoms. That means, when we look in an AD brain, we are looking at the very last stages of the proce
INTERVIEWS 1998-12-15 Interviews ARF: I appreciate your taking the time to talk to me. JT: I am pleased to do this, since, although my major focus as a biomedical researcher is to try to unravel the causes and mechanisms of neurodegenerative disorders such as Alzheimer's
CONFERENCE COVERAGE SERIES American Society for Cell Biology 38th Annual Meeting: Tau Protein in Neurodegenerative Diseases American Society for Cell Biology 38th Annual Meeting: More About Tau American Society for Cell Biology 38th Annual Meeting: Novel Protein Binds to APP and Mi
CONFERENCE COVERAGE 1998-12-12 Conference Coverage Maas et al. (Abstract 2285) studied how phosphorylation of two different regions in tau proteins affects binding of tau protein to the plasma-membrane (PM). The two major phosphorylation sites studied were those located just upstream o
CONFERENCE COVERAGE 1998-12-12 Conference Coverage Tau protein in Neurodegenerative Diseases A special interest subgroup meeting on 'Tau protein in Neurodegenerative Diseases' was organized by Gloria Lee, University of Iowa. This was a timely and stimulating meeting, that was
CONFERENCE COVERAGE 1998-12-12 Conference Coverage A special interest subgroup meeting on "Tau protein in Neurodegenerative Diseases" was organized by Gloria Lee, University of Iowa. This was a timely and stimulating meeting that was energized in large part by the recent disc
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