American College of Neuropsychopharmacology 2000 Annual Meeting

CONFERENCE COVERAGE SERIES Symposium: Gene Expression Profiling of Alzheimer's Disease American College of Neuropsychopharmacology 2000 Annual Meeting

Symposium: Gene Expression Profiling of Alzheimer's Disease

CONFERENCE COVERAGE 2001-01-08 Conference Coverage Annual Meeting of the American College of Neuropsychopharmacology, San Juan, Puerto Rico. At this meeting, the speakers discussed the sequence of changes in gene expression in the brain that may take place during the transition from no

Selegiline Does Not Increase Parkinson's Death Rate

RESEARCH NEWS 2000-12-23 Research News The drug selegiline, thought to be neuroprotective, has been used to treat Parkinson's disease for the past 25 years, but a report a few years ago suggested that the drug could accelerate death in patients taking it. A new study from Sc

New DNA Array Method Paves Way to "User's Manual" for Master Genes

RESEARCH NEWS 2000-12-22 Research News In today's issue of Science, researchers at the Whitehead Institute and Corning Inc. describe a new microarray technique that can decipher the function of master switches in a cell by identifying the set of genes they control across the

Blocking Aβ's Oxygen Radical Producing Power

RESEARCH NEWS 2000-12-21 Research News A study presented earlier this week at the 2000 International Chemical Congress of Pacific Basin Societies in Honolulu found that by manipulating the structure of amyloid-β, it was possible to reduce the peptide's ability to induce the

Society for Neuroscience Annual Meeting 2000

CONFERENCE COVERAGE SERIES Society for Neuroscience Annual Meeting: Stem Cells Drawn to Aβ Society for Neuroscience Annual Meeting: Stem Cells Promising for Motor Neuron Disorders Society for Neuroscience Annual Meeting: Does ApoE Contribute to Tangle Formation? Society for Neurosc

News Summary from the 40th Annual Meeting of The American Society for Cell Biology

CONFERENCE COVERAGE 2000-12-20 Conference Coverage San Francisco, 9-13 December 2000. Report by Mervyn J. Monteiro, University of Maryland Biotechnology Institute The 40th ASCB meeting began its grand kick-off on Saturday December 9 with an opening symposium by four Nobel Laureates, J.

More Vaccine Results in Nature

RESEARCH NEWS 2000-12-20 Research News A trio of articles will appear in tomorrow's issue of Nature, reporting that Aβ peptide immunization reduces a memory deficit in transgenic mouse models of AD. The findings from the University of Toronto and University of South Florida

Society for Neuroscience Annual Meeting: COX-2 Gene Expression Parallels AD Progression

CONFERENCE COVERAGE 2000-12-20 Conference Coverage The molecular and genetic mechanisms involved in the initiation and progression of Alzheimer’s disease (AD) are poorly understood. One emerging player in the proinflammatory cycle operating in AD brain is cyclooxygenase-2 (COX)-2, an i

Society for Neuroscience Annual Meeting: Down-regulation of Transcription Factors in AD

CONFERENCE COVERAGE 2000-12-20 Conference Coverage Widespread reports of changes in RNA message abundance and specific RNA message levels in senescent cultured primary neural cells, in normal aging human brain and especially in Alzheimer’s disease-afflicted neocortex and hippocampus su

Society for Neuroscience Annual Meeting: More Potential AD Gene Loci from NIMH Study

CONFERENCE COVERAGE 2000-12-20 Conference Coverage Bertram et al. (301.7), evaluated Alzheimer’s disease (AD) candidate genes and AD chromosomal regions of interest (`30 cM) from the whole genome scans available from the National Institutes of Mental Health-Alzheimer Disease ((NIMH-AD)

Society for Neuroscience Annual Meeting: Presenilin and COX-2 Expression Induced by Oxidative Stress

CONFERENCE COVERAGE 2000-12-20 Conference Coverage The presenilin-1 and-2 (PS1, PS2) genes encode integral transmembrane proteins putatively involved in cell-cell recognition, cell-fate determination, intercellular signaling and Aβ peptide formation. Cyclooxygenase-2 (COX-2), also a me

Society for Neuroscience Annual Meeting: Chromosome Missegregation Linked to PS Mutations

CONFERENCE COVERAGE 2000-12-20 Conference Coverage Presenilin-1 and-2 (PS1, PS2) gene mutations appear to cause the majority of cases of early onset familial Alzheimer’s disease (EO-FAD). In this presentation Potter et al. (492.2) presented data that PS1 and PS2 (the PS's) have a

Society for Neuroscience Annual Meeting: Role of Nicastrin-Presenilin Complexes

CONFERENCE COVERAGE 2000-12-20 Conference Coverage Presenilin-1 and-2 (PS1 and PS2) are members of a (growing) family of genes which encode polytopic integral transmembrane proteins homologous to the Notch cell surface receptors of Drosophila and the sel-12 element of the C. elegans ge

Immune Proteins Play Role in Brain Development and Remodeling

RESEARCH NEWS 2000-12-19 Research News Two immune proteins found in the brains of mice help the brain develop and may play key roles in triggering developmental disorders like dyslexia and neurodegenerative disorders like Parkinson's disease, according to a Harvard Medical S