George Perry on Marked increase of neuronal prion protein immunoreactivity in Alzheimer's disease and human prion diseases.

COMMENT Pathogenic versus Pathology Voigtlander and colleagues provide compelling supporting evidence for the notion that PrP is a neuroprotectant. Therefore, PrP, like amyloid-beta protein precursor/amyloid-beta in Alzheimer disease (AD), alpha-synuclein in Park

George Perry on Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid.

COMMENT Stalling the Ravages of Aging (and Alzheimer's?) With Antioxidants "Since its conception nearly 50 years ago (Harman, 1956), the free radical theory of aging has found some of its best support from studies of brain aging and Alzheimer disease (S

George Perry on Functional mitochondria are required for amyloid beta-mediated neurotoxicity.

COMMENT Mitochondria, Amyloid-β, and Metabolism Studies of amyloid-β (Aβ) cellular toxicity using cells with the full complement of organelles have implicated various sites of action but have primarily focused on the plasma membrane (Mark et al., 1997). Indeed, a

Alexei Koudinov on A novel mechanism for the regulation of amyloid precursor protein metabolism.

COMMENT Please see the following comments related to this article: Alzheimer's disease and amyloid

Alexei Koudinov on Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons.

COMMENT Please see the following comments related to this article: Alzheimer’s anti-amyloid vaccination

Alexei Koudinov on The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset.

COMMENT As a background reading please do not miss the following articles: Brain Cholesterol Pathology is the cause of Alzheimer’s disease Koudinov and Koudinova Clin Med Health Res clinmed2001100005, Published online November 27, 2001 [Full Text] 0 postmaster

Alexei Koudinov on Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease.

COMMENT Also please see the following comments related to this article: Alzheimer’s anti-amyloid

George Perry on Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

COMMENT Oxidative Abnormalities As The Earliest Changes In Amyloid-b Disease Determining the chronological and mechanistic interrelationship of Alzheimer disease (AD) is critical to both elucidating its etiology and developing efficacious therapeutics that are di

Alexei Koudinov on Evolution of beta-amyloid induced neuropathology: magnetic resonance imaging and anatomical comparisons in the rodent hippocampus.

COMMENT Please see the following comments related to this article: Alzheimer’s anti-amyloid vaccination

Alexei Koudinov on Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain.

COMMENT As a background reading please do not miss the following articles: Brain Cholesterol Pathology is the cause of Alzheimer’s disease Koudinov and Koudinova Clin Med Health Res clinmed2001100005, Published online November 27, 2001 [Full Text]  ; The emerging

Alexei Koudinov on beta-Amyloid neurotoxicity is exacerbated during glycolysis inhibition and mitochondrial impairment in the rat hippocampus in vivo and in isolated nerve terminals: implications for Alzheimer's disease.

COMMENT Also please see the following comments related to this article: Alzheimer’s anti-amyloid

Julian Thorpe on World Alzheimer Conference 2000: Pin1 Binds Both Tau and APP

COMMENT The part of this report referring to Davies's earlier work (with Lu) on Pin1 and tau (Lu et al) is completely misleading. I quote: "Davies and colleagues previously have shown that Pin1 is present in Alzheimer's tangles, and that its bindin

Alexei Koudinov on Cholesterol metabolism in the brain.

COMMENT As an additional reading please see the following: As a background reading please do not miss the following articles: Brain Cholesterol Pathology is the cause of Alzheimer’s disease Koudinov and Koudinova Clin Med Health Res clinmed2001100005, Published o

Alexei Koudinov on Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.

COMMENT Please do not miss the following letters to complete the above comment by Dr.Hardy: Alzheimer’s

Alexei Koudinov on Alzheimer's disease: plaques and tangles.

COMMENT Please see the following letters related to this article: Alzheimer’s anti-amyloid vaccination and statins: two approaches, one dogma. The time for change. Koudinov and Koudinova BMJ 20 March 2002 [Full Text]  ; Alzheimer's disease and amyloid beta p