Alexei Koudinov on Abeta42 plasma in the diagnosis of Alzheimer's disease.

COMMENT Also, please see the following comments related to this article: Alzheimer’s anti-amyloid

Alexei Koudinov on Tau, phospho-tau and Ab42 in cerebrospinal fluid in Alzheimer's disease.

COMMENT As a background reading please do not miss the article cited below. It suggests that the change in amyloid and tau biochemistry represents important compensatory event in brain metabolism/function: Brain Cholesterol Pathology is the cause of Alzheimer’s d

Alexei Koudinov on Cerebrospinal fluid 24S-hydroxycholesterol is increased in Alzheimer's disease compared to healthy controls.

COMMENT As a background reading please do not miss the following articles: Brain Cholesterol Pathology is the cause of Alzheimer’s disease Koudinov and Koudinova Clin Med Health Res clinmed2001100005, Published online November 27, 2001 [Full Text] 0 postmaster

Alexei Koudinov on Toxicity of beta-amyloid vaccination in patients with Alzheimer's disease.

COMMENT Also please see the following comments related to this article: Alzheimer’s anti-amyloid

Alexei Koudinov on Tau function and dysfunction in neurons: its role in neurodegenerative disorders.

COMMENT Also please do not miss the following articles: Brain Cholesterol Pathology is the cause of Alzheimer’s disease Koudinov and Koudinova Clin Med Health Res clinmed2001100005, Published online November 27, 2001 [Full Text] 0 postmaster

Alexei Koudinov on Therapeutic vaccines: realities of today and hopes for the future.

COMMENT Also please see the following comments related to this article: Alzheimer’s anti-amyloid

Alexei Koudinov on Reversal of amyloid beta toxicity in Alzheimer's disease model Tg2576 by intraventricular antiamyloid beta antibody.

COMMENT Also please see the following comments related to this article: Alzheimer’s anti-amyloid

Alexei Koudinov on Immunization delays the onset of prion disease in mice.

COMMENT Please see the following comments related to this article: Alzheimer’s anti-amyloid vaccination

Alexei Koudinov on Potential neurotoxic inflammatory responses to Abeta vaccination in humans.

COMMENT Also, please see the following comments related to this article: Alzheimer’s anti-amyloid

Alexei Koudinov on Cholesterol and Alzheimer's disease.

COMMENT Please be sure not to miss the following article: Brain Cholesterol Pathology is the cause of Alzheimer’s disease Koudinov and Koudinova Clin Med Health Res clinmed2001100005, Published online November 27, 2001 [Full Text] ; The emerging neurobiology of c

Nikolay Dokholyan on Interaction of intracellular beta amyloid peptide with chaperone proteins.

COMMENT Fonte et al. study an intracellular aggregation of Aβ in the transgenic C. elegance model they developed. Fonte et al. identify proteins that interact with Ab in vivo. The authors find six likely chaperone proteins (HSP70, HSP16 families, and a putative o

Inez Vincent on p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro.

COMMENT This study is signficant because it demonstrates that soluble extracellular Aβ can cause cdk5 activation and tau hyperphosphorylation. Also, the effects of Aβ on differentiated neurons are easier to interpret because under these conditions, other cell cyc

Inez Vincent on Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice.

COMMENT This paper is clealry of importance because of the prominent neurodegeneration induced by complement inhibition. It would be interesting to know what type of degeneration was seen, whether it involves cytoskeletal pathology, cell cycle abnormalities, and

Mary Sano on Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial.

COMMENT Does estrogen have a future in treating Alzheimer Disease? Comment by Mary Sano The Women’s Health

Benjamin Wolozin on Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy.

COMMENT This is an interesting paper that describes a growing body of work with potentially significant clinical impact. Winkler and colleagues, who hail from the laboratory of Mathias Jucker, have investigated a transgenic APP mouse that exhibits a large amount