Tomiichiro Oda on A novel compound, RS-1178, specifically inhibits neuronal cell death mediated by beta-amyloid-induced macrophage activation in vitro.

COMMENT The compounds RS-1178 and others as yet undisclosed are available for licensing upon request. Contact shigek@shina.sankyo.co.jp (S. Uryu) for more information. 0 odatom

M. Flint Beal on Bile Acid Proves Neuroprotective in Huntington's Model

COMMENT The recent study demonstrating that tauroursodeoxycholic acid exerts significant therapeutic effects in a transgenic mouse model of Huntington's Disease (HD) is extremely intriguing. This agent was previously demonstrated to stabilize mitochondria an

George Carlson on Mouse Genome Mapped

COMMENT The completion of a physical map for the mouse genome, in addition to being a major achievement of the Human Genome Project, will accelerate identification of genes involved in susceptibility to human diseases. The key strategy, which underlines the utili

Benjamin Wolozin on Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity.

COMMENT Until now, Parkin has been the principal ligase implicated in neurodegenerative processes. This current paper focuses attention on another ligase that participates in the cellular response to protein aggregates. 0 bwolozin

Benjamin Wolozin on Presenilins are not required for A beta 42 production in the early secretory pathway.

COMMENT Previous studies by Checler suggested that A β could be produced by cells lacking PS1 and PS2. This current paper provides support for this surprising result, and identifies the specific compartment in which the A β species is produced, which could help t

Benjamin Wolozin on Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.

COMMENT Understanding the membrane localization of Memapsin 2 (BACE 1) could be very important for understanding the factors that control its activity. This paper provides an interesting analysis of factors controling the endocytosis of Memapsin 2. 0 bwolozin

Judith Blake on Mouse Genome Mapped

COMMENT The recent paper in Nature on the physical mapping of the mouse genome provides a powerful resource in the public domain for the investigation of genetic components of human biology and disease. With this resource, scientists who have mapped the general l

Inez Vincent on p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro.

COMMENT In response to the comment by Tan, et al.: The use of primary rat neurons in Tsai's study and

Michael Mullan on p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro.

COMMENT Reply to Vincent comment, from J. Tan, T. Town and M. Mullan. To answer the first question, yes,

Fred Van Leuven on Presenilins are not required for A beta 42 production in the early secretory pathway.

COMMENT Adding this type of fuel to a scientific debate is exciting. In the light of what is known (and not known) of APP and PS1, i.e. their normal function and their contribution to AD, this paper cannot but raise more questions. Too many cooks can ruin the dis

Alexei Koudinov on The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

COMMENT Please do not miss the following comments related to this article: Alzheimer's disease and

Leigh Goodger on Towards an understanding of biological role of colostrinin peptides.

COMMENT The details of this paper is technical about colostrinin, but the drug I feel may be a potential cure for Alzheimer's. Further research in Poland by British-based ReGen Therapeutics has shown that colostrinin may slow down the effects of AD. Look at

Alexei Koudinov on Alzheimer beta-amyloid peptides: structures of amyloid fibrils and alternate aggregation products.

COMMENT Also please see the following comments related to this article: Alzheimer’s anti-amyloid

Alexei Koudinov on Alzheimer's Disease: Genes, Pathogenesis and Risk Prediction.

COMMENT Also, please see the following comments related to this article: Alzheimer’s anti-amyloid

Alexei Koudinov on Peptide aggregation in neurodegenerative disease.

COMMENT Also please do not miss the following comments related to this article: Alzheimer’s anti-amyloid