11621 RESULTS
COMMENT Polyadenylation is key to a number of nuclear functions, notably the regulation of mRNA stability and DNA repair. The extensive accumulation of polyA in neurons of polyA glycohydrolase mutant flies suggests that there is a major effect on mRNA stability i
COMMENT This interesting paper raises a number of technical questions in my mind. For one, I noticed that in Table 2, variance explained by genetics was significant for the younger series of twins, but apparently not for the older twin series. This would be consi
COMMENT Towards a Relevant Model of Alzheimer’s Disease Transgenic mice with mutated APP gene (APP) or APP+PS1 are models of the amyloidosis occurring in familial AD. Transgenic mice with tau are models of familial frontotemporal diseases. Transgenic mice with bo
COMMENT In response to the commentary by Robert Peers, I'd like to reply that part of his interpretation is plausible and part of it seems less likely to me. When Sally Frautschy and Marni Harris-White infused that particular preparation of Aβ oligomers into
COMMENT This article is mostly technical, and only preliminary data are shown. I realize this may sound severe, but I believe we should all keep this caveat in mind, especially given how we are urged to publish. Having said that, this work is full of promise. It
COMMENT up by the overexpressed proteinases or not? And I do want to quote from an old comment by Chris Exley
COMMENT endpoint that coincides with improved memory. However, I would like to add a more general comment on the
COMMENT I would like to ask Dr. Bush whether there is any evidence that clioquinol may inhibit SOD1 activity? Lee et al.(1) find that the neuronal adaptor protein X11α reduces Aβ levels. McLoughlin et al.(2) find that X11α interacts with the copper chaperone for
COMMENT Although this paper represents a tremendous amount of work, it is not as strong a study as the similar one conduced recently in the fruit fly (Giot et al., 2003). Li et al. used only about one-fifth the number of bait targets as used in the fly work, so t
COMMENT Regarding the paradoxical actions of TGFβ in brain, where the factor appears to be either protective against neuronal degeneration, as reported in this study, or deleterious, promoting inflammation, hydrocephalus, and vascular fibrosis and amyloidosis, (W
COMMENT Amyloid-β Oligomers: Were They Ever Bad? I read with interest the ARF news story on the 33rd Society for Neuroscience Annual Meeting 2003 presentation by Harris/White et al. (abstract 240.11). This is because, in our recent study, we showed that amyloid-
COMMENT There are many reasons for believing that Aβ peptides, in one form or another, are important factors in the pathogenesis of AD. Although some investigators are skeptical that these peptide are necessarily the most important factors leading to this disease
COMMENT Every try is a necessary step to best treatment. jux1 0
COMMENT A fatty diet produces oxidative stress, as seen in diabetics, whose urine contains elevated levels of oxidized DNA base products (8-OHdG)—also seen in cases of breast cancer, which has now been firmly linked to a fatty diet (Bingham et al., 2003). How can
COMMENT This curious effect of β-peptide oligomers, in first enhancing, then impairing cognition in rats, may have an explanation, as follows: Such oligomers are toxic in Alzheimer's disease because they cause synaptic lipid peroxidation, especially in brain
