11622 RESULTS
COMMENT Akiyama and McGeer describe focal clearance of senile plaques in the cortex of a patient with Alzheimer’s disease in an advanced stage. They interpret this as a result of “microglia and macrophage invasion of the affected area.” Their data are remarkable
COMMENT The manuscript by Blalock et al. is one of the most comprehensive and intriguing postmortem DNA microarray studies to date. Importantly, this manuscript goes beyond the “most changed gene” concept, and focuses on the transcript networks putatively affecte
COMMENT ERK activation has been associated with the regulation of three major features of relevance to Alzheimer’s disease; these are hyperphosphorylation of tau (p-tau); memory and learning processes; and neurodegeneration. MEK1 is the upstream activator of ERK,
COMMENT Not that easy to make a relevant model of AD! 0 andre.delacourte
COMMENT PIB-PET probing is a very significant step foreward on the road to early Alzheimer diagnosis. The authors deserve sincere congratulations on this significant contribution. However, in order to be generally applicable new techniques should be affordable, w
COMMENT The findings by Emamian and colleagues provide advances in our understanding of the mechanisms underlying the pathophysiology of schizophrenia. However, many questions remain to be addressed: 1. How does an alteration in AKT1/GSK3β signaling contribute to
COMMENT This report on a connection between AKT-GSK3β signaling and schizophrenia provides evidence showing that schizophrenia and AD might have a common signaling cascade defect. Investigating the levels of AKT and Ser 9 phosphorylated GSK3β (pS9GSK3β) in the ly
COMMENT cell death during embryogenesis. Again, these functions are not exclusive. Q: In her comment, Elena
COMMENT A possible target to neutralize an important risk factor of Alzheimer's disease. 0 andre.delacourte
COMMENT An additional paper showing new evidence that the gamma or epsilon APP-CTF stubs could be vital gene modulators. 0 andre.delacourte
COMMENT That PS1 keeps a most amazing profile is no longer a surprise, but the results reported now by J. Singer and colleagues will certainly invigorate the debate about the "firmness" of some concepts. First, let's recall the data of this same gr
COMMENT This paper revisits the issue of presenilin topology, providing further evidence of a 7-TM model with an orientation opposite those suggested from many other studies. With new antibodies in hand, Dewji and colleagues detected the PS1 N-terminus and a larg
COMMENT In relation to the possible role of Abeta peptides in memory and learning processes, I would like to mention that the results that we obtained (presented in NSF meeting 2003 Echeverria V, Ducatenzeiler A and Cuello C) analyzing the influence of the Ab-ind
COMMENT I would like to correct a brief comment on our SfN abstract. Although we wrote that trimers do not
COMMENT Jeon et al. (1) suspect that the pyrogallol moiety on C-2 and/or C-3 of the catechin skeleton is responsible for the increased inhibition of BACE1 by these green tea catechins. It seems of interest that Bain et al. (2) have found that epigallocatechin-3-g
