11622 RESULTS
COMMENT Changes in brain lipid composition have been determined in 24 month-old Fischer rats compared with 6 months-old ones. The cerebral levels of sphingomyelin and cholesterol were found to be significantly increased in aged rats, whereas the amount of phospha
COMMENT The NEJM article is good for reminding us that blocking muscarinic receptors may impair cognition and alter perception in anyone, but especially in the elderly. As loss of cortical cholinergic afferents is a normal aging change in humans, the elderly are
COMMENT Cell Cycle Signaling, DNA Damage and Neuronal Apoptosis Three years ago, following an extensive review of the literature, my colleagues and I came to a hypothetical model on the relationship among cell cycle signaling, DNA damage, and neuronal apoptosis [
COMMENT My father, suffering from severe dementia, was on the drug zyprexa. He was suffering from hallucinations. He thought there were people in the house who were not there. He thought my mother was someone else. He had a massive stroke 2 weeks ago and died! Th
COMMENT This work makes the epsilon cleavage of APP more important in understanding the mechanism of gamma-secretase action. It would be interesting to know whether FAD mutations in presenilin influence epsilon cleavage of APP and APLPs. 0 saido
COMMENT The function of APP remains unknown, but it has long been assumed that APP is a receptor. Indeed, the title of one of the original papers reporting the cloning of APP was “The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface re
COMMENT DNA Damage Mediated Cell Cycle Reentry in AD The search to elucidate pathologic mechanisms of neuronal death in Alzheimer's disease has demonstrated that dysregulation of two major cellular processes—cell cycle control and response pathways to oxidat
COMMENT Lipids May Play an Important Role in AD Pathogenesis It has long been recognized that lipid alterations play an essential role in many major diseases such as diabetes, obesity, atherosclerosis, and myocardial dysfunction (see Stanley, 2001; Unger & Or
COMMENT No surprise at all. As dementia patients are already at higher risk for stroke due to metabolic disturbances that are already there, both in vascular and Alzheimer's disease, not mentioning age alone...The real question is whether this is the beginni
COMMENT Great paper, nicely written. 0 caliban
COMMENT Ceramide, Cholesterol, and Oxidative Stress In a very exciting study, Cutler and colleagues provide insight to link membrane-associated oxidative stress and neuronal degeneration in aging and Alzheimer disease (AD). Many lines of evidence suggest that oxi
COMMENT Comment by Thierry Nouspikel and Philip C. Hanawalt Alzheimer Neurons Reentering the Cell Cycle:
COMMENT This is a very interesting finding in line with our publicaion. We have published already our finding on trace metal increase in moderately affected AD brain compared to control. In particular, we found that Zn was higher than other elements Si, Cu, Mg, C
COMMENT Three recent articles (refs. 1, 2, and 3) have suggested that sphingolipid metabolism may be involved in the pathogenesis of Alzheimer’s disease (AD). The first one, from Xianlin Han and colleagues (1), has identified a ~threefold increase in ceramide lev
COMMENT This article provides an intriguing link among aging, oxidation, ceramides, and cholesterol. Mark Mattson’s group analyzed the brain content of sphingomyelin and ceramides in young and old animals. They observed a striking >100-fold increase in the lev
