11631 RESULTS
COMMENT This paper describing the effects of Taxol on axonal transport deficits in a tauopathy mouse model represents a milestone in drug discovery efforts for a number of reasons, not the least of which is the targeting of tau rather than amyloid neurofibrillary
COMMENT Since the appearance of the first epidemiological and animal studies claiming a connection between cholesterol and Alzheimer disease, at least four different aspects of cholesterol metabolism have been directly linked to AD neuropathology: (i) clustering
COMMENT Peripheral Diagnosis of Signaling Intermediates in Alzheimer Disease The need for accurate diagnostics in Alzheimer disease is one of the most pressing issues in the field today, and this is especially true for diagnostic tools, which employ easily attain
COMMENT Statins are known to increase secretion of APP, but the mechanism by which this occurs is poorly understood [1]. The current manuscript by Pedrini et al. focuses on the effect of statins on Rho and Rho-associated coiled-coil containing kinase 1 (ROCK). Th
COMMENT Antipsychotic medications include haloperidol, thiothixine, trifluoperazine, perphenazine, thioridazine, and then the newer antipsychotics, clozapine, risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole. The latter are called “atypical” or
COMMENT Further evidence that α-synuclein gene dosage mutations are rare In this simple paper, the authors screened for SNCA gene dosage mutations in a cohort of 190 unrelated PD patients who presented with a positive family history. No mutations were identified,
COMMENT This article is original, well thought out, persuasive in its logic. 0 bill.glimm
COMMENT This paper describes a correlation between prion infection and increase in NICD. To establish a causative role for Notch in the pathology, the authors reproduce the observations establishing that Notch can control neurite outgrowth in cell lines. These tw
COMMENT This article shows that the Notch intracellular domain (NICD), the proteolytic fragment that mediates signaling from the Notch receptor, is increased in prion-infected CD1 mice, and this increase correlates with dendritic atrophy. Moreover, cultured neuro
COMMENT Notch signaling is a highly conserved pathway that plays essential roles in cell proliferation and differentiation. It is unclear, however, whether Notch-1 signaling does participate in cellular events leading to neurodegeneration. In this, S. J. DeArmond
COMMENT Finding the conditions that allow ES cells to maintain their dopaminergic phenotype in vivo has proved to be a challenge. If Takagi and colleagues have found a method of doing so, it would represent an important advance for the field. However, the fact th
COMMENT Scaling-up growth factor therapy for ALS Amyotrophic lateral sclerosis (ALS) is the most aggressive of the major adult-onset neurodegenerative disorders. Despite important progress in the understanding of ALS pathogenesis, there is still no effective ther
COMMENT Mitochondria in Alzheimer Disease: Pulling the Plug on the Synapse Zheng Li and colleagues provide compelling data and discussion to confirm the growing suspicion that proper mitochondrial structure and function are requisite for synaptic operation. Indee
COMMENT Curcumin also impacts aluminum binding to chromatin DNA, which is of relevance. After aluminum mordanting of chicken blood smears, several chelating dyes and reagents were found to detect metal binding to chromatin DNA by fluorescence microscopy. One of t
COMMENT The results showing increased cardiovascular risk of patients taking COX-2 inhibitors, or a non-selective COX inhibitor, may come as a surprise in the face of extensive research on role of macrophages in atherosclerosis. The results of current animal stud
