Paul Aisen on Safety Concerns Halt ADAPT Trial

COMMENT Without seeing the data, I cannot comment on the decision to halt ADAPT. But note that in 2000,

Nikolaos Tezapsidis on Linking Leptin to AD

COMMENT for your comments on our paper which describes a possible link between leptin and AD-related pathways.

Charles Glabe on Conformation Rules Part 2: News, Common Threads, Debate from San Diego Protein Misfolding Conference

COMMENT Reply by Charlie Glabe With regard to the question of our recent work and the channel hypothesis, our work supports the general tenet of the channel hypothesis in that amyloid oligomers permeabilize membranes. The details are different because we do not o

James Bowie on Conformation Rules Part 2: News, Common Threads, Debate from San Diego Protein Misfolding Conference

COMMENT This news summary states that Dr. Glabe's work weakens the channel hypothesis. On the contrary, I think his work is completely consistent with and supports the basic premise of the model, i.e., membrane disruption and loss of ion homeostasis. Where h

William Klunk on In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent.

COMMENT Many researchers and clinicians agree that there is great value in developing imaging technologies for the quantitation of amyloid deposition in human brain. Potential benefits of this effort include improved diagnosis of AD, particularly in early and con

Mark Cookson on BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.

COMMENT The experiments presented by the Lazano group are solid because the authors have been careful to cover as many bases as they can to test their major hypothesis: that BAG5 is a natural inhibitor of parkin function. But as well as being careful science, the

George Perry on Linking Leptin to AD

COMMENT Leaping on Leptin: What’s the Skinny? The work by Fewlass and colleagues [1] provides an impressive array of data suggesting that leptin hormone homeostasis and/or dysregulation bears upon the metabolism of amyloid-β (Aβ). Although not confirmed by neurop

Edward Khandjian on On-Demand Dendritic Proteins Served Up with Help of Fragile X Protein

COMMENT This is a timely report, since it has been recently shown that FMRP is definitely associated with brain polyribosomes (see Stefani et al., 2004 and Khandjian et al., 2004). The data reported by Weiler et al. show that synaptoneurosomes from the Fragile X

John (Wes) Ashford on Proteomic analysis of in vivo phosphorylated synaptic proteins.

COMMENT With reference to Alzheimer disease and memory mechanisms, this paper identifies 600 phosphorylation sites on synapses. Synapse formation and destruction are critical aspects of memory. Further, phosphorylation is a critical part of synaptic plasticity, a

Jorge Parodi on Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

COMMENT This is a good paper, suggesting a new focus, and I only have one question. Is it clearance of soluble Aβ or aggregated Aβ? 0 jparodi

Jorge Parodi on Cytosolic phospholipase A2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid-beta peptide.

COMMENT I read the paper and enjoyed the new view presented by these authors.... However, I do not understand the definition of "soluble oligomer." Is this a protofibrillar solution? Are amylospheroids in the sample? Or is there just monomer in the solu

john shaner on Genetic association of low density lipoprotein receptor and Alzheimer's disease.

COMMENT I have always wondered if much higher than normal HDL could have an effect. I only know of one person who has such a condition and that person has now developed dementia problems. 0 ejshaner

Christopher Eckman on Obesity-related leptin regulates Alzheimer's Abeta.

COMMENT This is a thorough and fascinating report by Nikolas Tezapsidis that shows a clear association between leptin and Aβ levels, at least when leptin is introduced into a variety of experimental systems, including the Tg2576 mouse model. It will be important

Benjamin Wolozin on Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease.

COMMENT This paper adds to an increasing body of literature indicating that chaperones modulate neurodegenerative disease. 0 bwolozin

Benjamin Wolozin on Genetic association of low density lipoprotein receptor and Alzheimer's disease.

COMMENT This provides evidence of yet another cholesterol-related protein that might be associated with Alzheimer disease. 0 bwolozin