11633 RESULTS
COMMENT This is an important finding, from experiments on rat tissue, that supports epidemiological evidence to date and suggests related mechanisms for how high levels of dietary fat might weaken cells and lead to dementia, including inflammation. 0 nemerson
COMMENT The abstract contains important information and I look forward to reading the entire paper. Their findings might have implications for both the potential and limits of healthy lifestyles and/or pharmacological interventions to delay onset of AD in those g
COMMENT These data are also very consistent with the suggestion that changes in Abeta production, or changes in the ratio of its various forms, are not the main causative agent of FAD. 0 nikos.robakis
COMMENT α-synuclein is frequently described as a “natively unfolded” or random coil protein (i.e., it exists in an ensemble of unordered conformations in vitro). Two papers published in the last two weeks, including the one by Bertoncini et al., provide more evid
COMMENT There is epidemiological data associating higher intake of calories and fats with increased risk of Alzheimer disease (AD), in particular among individuals carrying the apolipoprotein E4 (ApoE4) allele (Luchsinger et al., 2002). Moreover there is also exp
COMMENT I sincerely thank Alzforum for publishing my provocative comment on AD and cholesterol, albeit
COMMENT This paper highlights an extremely important (but, unfortunately, often neglected) topic in the Alzheimer research community. Despite the plethora of research efforts and breakthroughs in areas such as genetics and immunology, details about the molecular
COMMENT I think these are very interesting papers from the AD point of view, especially since PS1 is involved in the PI3K/Akt pathway which regulates GSK3 and its downstream target CRMP-2. Specifically it has been shown (see Baki et al., 2004) that PS1 downregula
COMMENT 1136 In the last issue of Cell, Jiang et al. and Yoshimura et al. have published two excellent articles about the role of GSK3 in determining neuronal polarity. In most cases, a neuron has a single axon and several dendrites. This type of neuronal polarit
COMMENT Using a modified gel electrophoresis system, these investigators describe a series of longer forms of amyloid-β peptides in both transfected cells and transgenic brain tissue. These peptides include some that are 45, 46, and 48 amino acids long, which the
COMMENT Dodart and coworkers use hippocampal injection of lentiviral vectors expressing the human isoforms of ApoE to demonstrate that ApoE2 reduces amyloid burden in PDAPP mice. These results suggest that ApoE2 may be a viable candidate for gene therapy in the t
COMMENT In their recent PNAS paper, Dodart and colleagues have shown that modulation of brain ApoE through a lentiviral gene delivery approach alters the level of hippocampal Aβ and its deposition in the PDAPP mouse model of AD. Their results confirm and extend t
COMMENT Sam Gandy’s group’s study underscores an emerging role for isoprenoid-mediated regulation of APP processing and its possible relationship to Alzheimer disease pathogenesis. Over a year ago, we reported that GGPP, one of the isoprenoids synthesized in the
COMMENT What a stunning turnaround in a field wherein people thought as late as 1997, and some even thereafter, that genetics were irrelevant to PD and it was all about environment! In the light of the MPTP story, obviously also an important advance, the field la
COMMENT These papers show that the G2019S mutation in LRRK2/dardarin is the most common single gene mutation associated with PD. Assuming that the change is pathogenic, this is an astounding result and would account for around 5 percent of cases with a clear domi
