11346 RESULTS
COMMENT This study combines data from a group of primary care practices and from the BioFINDER study to analyze the value of plasma %p-tau217 (measured as part of the C2N Precivity2 assay and compared against the p-tau217 percentage occupancy alone) in improving
COMMENT I share Dr. Jucker's skepticism for what is reported as being detected by the Aβ (OC+) antibody used. We have found several different antibodies to label similar clusters adjacent to the foot processes of GFAP-labeled astrocytes in older mice. We ha
COMMENT We are very pleased that our study uploaded on bioRxiv, on proteostasis as a fundamental principle of Tau immunotherapy, is now out in the journal Brain. j.goetz 0 Proteostasis as a fundamental principle of Tau immunotherapy.
COMMENT I think this is a fascinating and timely research article, demonstrating that the propagation of slow waves across the neocortex during sleep is impaired in older individuals. This impairment is correlated to the degree of tau tangle pathology in the brai
COMMENT This is an exciting resource and accompanying manuscript which demonstrates the critical importance of multiregional brain profiling to define molecular cellular phenotypes of brain disease. By sampling multiple regions at different stages of disease, the
COMMENT This study is a landmark in AD research because of its detailed cellular and molecular characterization of postmortem human brain samples. Previously, the same group published an snRNA-Seq database of hundreds of cases from one brain region. In this study
COMMENT This study provides a comprehensive Rosetta stone for a multiregional, multicellular data mining atlas for Alzheimer’s disease. Importantly, the authors identified molecular architecture and cellular subsets for cognitive resilience to AD pathology. Furth
COMMENT This is a very comprehensive study, which was done in a careful manner by experts in the field. I have only one major concern, and that is how A plaques and tau tangle pathology are compared to flortaucipir retention. The flortaucipir PET signal is quant
COMMENT This is an excellent and important study reporting on the largest antemortem tau PET (combined with amyloid PET) versus autopsy dataset to date. The main goal of the study was to investigate the relationships between tau and amyloid pathology based on inf
COMMENT Monroe, Blurton-Jones, and colleagues report on one of the myeloid-specific genetic targets, PILRA, that modulates AD risk. PILRA knockout microglia display lipid droplet accumulation but maintain homeostasis in an inflammatory environment by showing incr
COMMENT This study uncovers the underlying mechanism of PILRA, whose loss-of-function variant is associated with reduced risk of AD, in regulating microglia. The authors found that CRISPR-mediated PILRA KO microglia (iMg) increased ApoE uptake, lipid droplet form
COMMENT In this study, Weerakkody and Sabelström et al. make a fascinating discovery in showing that PILRA KO microglia accumulate lipid droplets yet exhibit enhanced microglial function and reduced proinflammatory responses, suggestive of a protective microglial
COMMENT This study on the molecular and cellular impact of PILRA loss of function (LoF) in human microglia exemplifies how to translate statistical associations between common variants and AD risk, identified by GWAS, into novel etiological and therapeutic hypoth
COMMENT Neuroinflammation is a central feature of Alzheimer’s disease. Several factors that impinge on microglial and astrocyte function modify neurodegenerative outcome. While outright removal of microglia has been observed to be detrimental (Munro et al., 2024)
COMMENT This really exciting study is moving the needle in how we understand the impact of AD risk loci on cellular pathways in the brain that contribute to disease. An interesting finding from this work is the way in which PILRA may interact with APOE to impact
