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COMMENT This article from the Takashima laboratory makes excellent use of the tau::Cry2 system to explore mechanisms of tau aggregation. The CRY2 system was first used to optically induce liquid-liquid phase separation (LLPS) of RNA-binding proteins by the Brangw
COMMENT Xie et al. used several advanced approaches to determine the molecular and morphologic profile of microglia in the early phase (three weeks) in a mouse model of ALS. The authors report an increase in cortical microglia that have unique rod shape. These mi
COMMENT In this study, Rosenzweig and colleagues used comprehensive transcriptomic profiling and multiplex flow cytometry of human blood neutrophils to reveal an immunosuppressive neutrophil subpopulation that expands in female APOE-ε4 carriers who have cognitive
COMMENT This study entangles an interesting observation related to the detection of “rod-shaped” microglia in ALS pathology. RNA-Seq analysis identified a cluster of disease-associated microglia (DAM) enriched in Lgals3 (Galectin-3) expression in a mouse model of
COMMENT biology: Translation and comments on Pío del Río-Hortega 1919 series of papers on microglia. An update on
COMMENT Our published paper now also includes much-improved sub-tomogram averaging of in-tissue tau filaments, using Warp/M and Relion, developed by Dimitry Tegunov at Genentech and Sjors Scheres at the Medical Research Council Laboratory for Molecular Biology, r
COMMENT This exciting paper beautifully complements previous work showing the role of microglial C1q in synaptic pruning during neurodevelopment and neurodegeneration alike (Stevens et al., 2007; Hong et al., 2016; Wilton et al., 2023). This paper elegantly revea
COMMENT In Alzheimer's disease, microglia are activated when they recognize the Aβ peptide, secreting a variety of inflammatory factors and neurotoxins, leading to neuronal damage/death. One of these factors, the complement C1q, is thought to modulate phagoc
COMMENT Overall, this manuscript provides provocative novel observations and hypotheses that expand our knowledge of the potential roles of C1q, a recognition component of the innate immune system and of the classical complement pathway. C1q has been shown to be
COMMENT This exciting and thought-provoking work by Scott-Hewitt et al. uncovers a new intraneuronal function for the microglial secreted protein C1q. The authors performed C1q co-immunoprecipitation from synaptosomes isolated from developing, young adult, and ad
COMMENT The study unveils the fascinating and unexpected discovery that C1q regulates protein homeostasis in the aging brain independently of its role in the complement pathway. Our research, along with that of others, including Beth Stevens’ lab, has demonstrate
COMMENT This is an incredibly well-done and compelling study that convincingly demonstrates that a microglial-derived protein is taken up by neurons and modulates their function. We know that C1q has a diverse array of functions, particularly in the extracellular
COMMENT Until about 10 years ago, neutrophils were considered a homogenous population of short lived, terminally differentiated cells with low transcriptional capacity that release a limited number of cytokines, suggesting highly conserved, specialized immune and
COMMENT The study by Rosenzweig et al. on the sex-dependent interactions between APOE4 neutrophils and microglia in Alzheimer's disease is very interesting and important. The authors have elegantly demonstrated the critical role of IL-17 signaling in cogniti
COMMENT This study is of interest as it provides new insights into the sex dependence of the impact of ApoE4 on AD pathobiology. The inclusion of human data combined with experimental validation are major strengths of the paper. The identification of a new class
