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PAPER Augusto-Oliveira M, Arrifano GP, Leal-Nazaré CG, Chaves-Filho A, Santos-Sacramento L, Lopes-Araujo A, Tremblay MÈ, Crespo-Lopez ME
Morphological diversity of microglia: Implications for learning, environmental adaptation, ageing, sex differences and neuropathology.
Neurosci Biobehav Rev. 2025 Mar 4;172:106091. Epub 2025 Mar 4 PubMed.PAPER Peng XQ, Guo HS, Zhang X, Wu XY, Ruganzu JB, Wu SD, Zhao MT, Li L, Yang Y, Ji SF, Yang WN, Ren PY
TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice.
Exp Neurol. 2025 Mar 4;388:115205. Epub 2025 Mar 4 PubMed.PAPER Battisti A, Ortore MG, Vilasi S, Sgarbossa A
FLIM-Phasor Analysis (FLIM-ϕ) of Aβ-Induced Membrane Order Alterations: Towards a Cell-Based Biosensor for Early Alzheimer's Disease Diagnosis.
Micromachines (Basel). 2025 Feb 19;16(2) PubMed.PAPER
Correction to "Pharmacotherapy for behavioural manifestations in frontotemporal dementia: An expert consensus from the European Reference Network for Rare Neurological Diseases (ERN-RND)".
Eur J Neurol. 2025 Mar;32(3):e70108. PubMed. Corrected paper.PAPER Wilde JH, Sun YY, Simpson SR, Hill ER, Fu Z, Bian EJ, Kinkaid MM, Villanueva P, Weybright AF, Terrell WR, Qureshi Z, Perera SS, Sheppard HS, Stone JR, Kundu BK, Kuan CY, Neumann KD
A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system.
Nat Biomed Eng. 2025 Mar 5; Epub 2025 Mar 5 PubMed.PAPER
Retraction: Larson et al., "Soluble α-Synuclein is a Novel Modulator of Alzheimer's Disease Pathophysiology".
J Neurosci. 2025 Mar 12;45(11) PubMed. Retracted Paper.PAPER Zheng Y, Yang J, Li X, Qi L, Zheng Z, Kong J, Zhang G, Guo Y
Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration.
Neurobiol Dis. 2025 Mar 4;208:106862. Epub 2025 Mar 4 PubMed.Fragments of Tau’s Microtubule Binding Region Mess with Synapses
RESEARCH NEWS 2025-03-06 Research News When under stress, neurons crank out tau fragments, and many scientists blame this for the propagation of tangle pathology in Alzheimer’s disease. The fragments also directly compromise synapses they encounter along the way, according to a p
Kanta Horie on Fragments of Tau’s Microtubule Binding Region Mess with Synapses
COMMENT This study investigated what tau species are capable of inducing synaptotoxicity, by measuring LTP in rats injected with AD brain extracts or with secretomes of iPSC-derived neurons from individuals with Down’s syndrome. The study design includes the immu
PAPER Ondrejcak T, Hu N-W, Coode E, Campbell T, Corbett GT, Doykov I, Mills K, Walsh DM, Livesey FJ, Rowan MJ, Klyubin I
Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region
bioRxiv2025.02.21.639417 .PAPER Qi C, Lövestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SH, Goedert M
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.
Nat Struct Mol Biol. 2025 Mar 5; Epub 2025 Mar 5 PubMed.Can Autoimmunity Spark Alzheimer’s Disease?
RESEARCH NEWS 2025-03-06 Research News Alzheimer’s may be, at least in part, a disease of the immune system. Evidence supporting this comes from the study of genetics, infectious diseases, and the molecular machinations of the innate and adaptive immune systems in the brain. Now,
Michael Guo on Whole Genome Variable Number Tandem Repeat Analysis in Alzheimer Disease.
COMMENT The authors leverage cutting-edge tools to large sequencing datasets in order to examine Variable Number Tandem Repeats, which, given their repetitive nature, have been traditionally very challenging to study at scale. The authors find multiple VNTRs that
PAPER Heath A, McNerney MW, Yesavage J
Whole Genome Variable Number Tandem Repeat Analysis in Alzheimer Disease.
Neurol Genet. 2025 Apr;11(2):e200241. Epub 2025 Feb 14 PubMed.Current Filters
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