Wilde JH, Sun YY, Simpson SR, Hill ER, Fu Z, Bian EJ, Kinkaid MM, Villanueva P, Weybright AF, Terrell WR, Qureshi Z, Perera SS, Sheppard HS, Stone JR, Kundu BK, Kuan CY, Neumann KD. A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system. Nat Biomed Eng. 2025 Mar 5; Epub 2025 Mar 5 PubMed.
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University of Kansas
A PET ligand that reveals oxidative stress in the human brain will facilitate work within the AD research field on a number of levels. It will help investigators get a glimpse into oxidative stress in the brains of AD patients. From there, investigators can speculate why the ligand signal in AD patients may deviate from controls (if one presumes the patterns indeed deviate). This part may prove to be challenging, but within the context of other PET ligand surveys, such as a ligand that shows complex I protein levels and perhaps TSPO also, it may help to flesh out a broader picture of bioenergetic metabolism and its consequences. Most directly, though, I suspect it may get the field closer to more useful and applicable target engagement biomarkers for studies evaluating bioenergetics-targeted therapeutic targets.
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