PAPER Sun W, Ye S, Wang Y, Chen H, Che P, Chen J, Zhang N

Plasma biomarkers for diagnosis and differentiation and their cognitive correlations in patients with Alzheimer's disease.

Brain Commun. 2025;7(2):fcaf094. Epub 2025 Feb 25 PubMed.

PAPER Fjell A, Rogeberg O, Sørensen Ø, Amlien I, Bartres-Faz D, Brandmaier A, Cattaneo G, Duzel S, Grydeland H, Henson R, Kühn S, Lindenberger U, Lyngstad T, Mowinckel A, Nyberg L, Pascual-Leone A, Sole-Padulles C, Sneve M, Solana J, Stromstad M, Watne L, Walhovd KB, Vidal D

Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries.

Res Sq. 2025 Feb 10; PubMed.

PAPER Chen Y, Yang X, Li J, Luo H, Huang Q, Yang W, Lei T, Lui S, Gong Q, Li H, Wu H, Gao H

A nasally administrated reactive oxygen species-responsive carrier-free gene delivery nanosystem for Alzheimer's disease combination therapy.

J Control Release. 2025 Mar 3;381:113604. Epub 2025 Mar 3 PubMed.

PAPER Jeejan J, Rao L, Sadasivan S, Lopes R, Dsouza N

Impact of cysteine mutations on the structural dynamics and functional impairment of SOD1: insights into the pathogenicity of amyotrophic lateral sclerosis.

Genomics Inform. 2025 Mar 6;23(1):7. PubMed.

PAPER Augusto-Oliveira M, Arrifano GP, Leal-Nazaré CG, Chaves-Filho A, Santos-Sacramento L, Lopes-Araujo A, Tremblay MÈ, Crespo-Lopez ME

Morphological diversity of microglia: Implications for learning, environmental adaptation, ageing, sex differences and neuropathology.

Neurosci Biobehav Rev. 2025 Mar 4;172:106091. Epub 2025 Mar 4 PubMed.

PAPER Peng XQ, Guo HS, Zhang X, Wu XY, Ruganzu JB, Wu SD, Zhao MT, Li L, Yang Y, Ji SF, Yang WN, Ren PY

TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice.

Exp Neurol. 2025 Mar 4;388:115205. Epub 2025 Mar 4 PubMed.

PAPER Battisti A, Ortore MG, Vilasi S, Sgarbossa A

FLIM-Phasor Analysis (FLIM-ϕ) of Aβ-Induced Membrane Order Alterations: Towards a Cell-Based Biosensor for Early Alzheimer's Disease Diagnosis.

Micromachines (Basel). 2025 Feb 19;16(2) PubMed.

PAPER

Correction to "Pharmacotherapy for behavioural manifestations in frontotemporal dementia: An expert consensus from the European Reference Network for Rare Neurological Diseases (ERN-RND)".

Eur J Neurol. 2025 Mar;32(3):e70108. PubMed. Corrected paper.

PAPER Wilde JH, Sun YY, Simpson SR, Hill ER, Fu Z, Bian EJ, Kinkaid MM, Villanueva P, Weybright AF, Terrell WR, Qureshi Z, Perera SS, Sheppard HS, Stone JR, Kundu BK, Kuan CY, Neumann KD

A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system.

Nat Biomed Eng. 2025 Mar 5; Epub 2025 Mar 5 PubMed.

PAPER Zheng Y, Yang J, Li X, Qi L, Zheng Z, Kong J, Zhang G, Guo Y

Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration.

Neurobiol Dis. 2025 Mar 4;208:106862. Epub 2025 Mar 4 PubMed.

PAPER

Retraction: Larson et al., "Soluble α-Synuclein is a Novel Modulator of Alzheimer's Disease Pathophysiology".

J Neurosci. 2025 Mar 12;45(11) PubMed. Retracted Paper.

Fragments of Tau’s Microtubule Binding Region Mess with Synapses

RESEARCH NEWS 2025-03-06 Research News When under stress, neurons crank out tau fragments, and many scientists blame this for the propagation of tangle pathology in Alzheimer’s disease. The fragments also directly compromise synapses they encounter along the way, according to a p

Kanta Horie on Fragments of Tau’s Microtubule Binding Region Mess with Synapses

COMMENT This study investigated what tau species are capable of inducing synaptotoxicity, by measuring LTP in rats injected with AD brain extracts or with secretomes of iPSC-derived neurons from individuals with Down’s syndrome. The study design includes the immu

PAPER Ondrejcak T, Hu N-W, Coode E, Campbell T, Corbett GT, Doykov I, Mills K, Walsh DM, Livesey FJ, Rowan MJ, Klyubin I

Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region

bioRxiv2025.02.21.639417 .

PAPER Qi C, Lövestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SH, Goedert M

Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.

Nat Struct Mol Biol. 2025 Mar 5; Epub 2025 Mar 5 PubMed.