Dietmar Thal on Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer’s disease
COMMENT We are grateful for the comments on our recent manuscript. We thank Dr. Walker for his statement
12 RESULTS
COMMENT We are grateful for the comments on our recent manuscript. We thank Dr. Walker for his statement
COMMENT In this interesting paper, Greg Lemke uses the somewhat provocative term granuloma to highlight the reactive/resorptive nature of the glial cell response around plaques. This reactive and resorptive response has been discussed in our field for years, thou
COMMENT Lee et al. investigated autolysosomal acidification using a novel, dual-tagged autophagy sensor in TRGL mouse brain. This sensor was built by pH-resistant mRFP together with pH-sensitive eGFP and LC3 (= tfLC3). Like LC3, the tfLC3 sensor is located in aut
COMMENT Kang et al. found that the primary residue Lys 353 of the τ protein reacts with the norepinephrine metabolite DOPEGAL. This interaction stimulates the accumulation of abnormal phosphorylated τ (p-τ), as well as its aggregation and propagation. This proces
COMMENT Johnson et al. analyzed prefrontal cortex samples from 516 donors using tandem-mass-tag mass spectrometry (TMT-MS) to generate a deep TMT network of AD-related proteins. This method allows a higher resolution for the detection of proteins compared to labe
COMMENT Wennström et al. report the histopathological analysis of p-tau217 in AD, PART, and control brains and its correlation to plasma p-tau217. An interesting finding is that p-tau217 was not only observed in neurofibrillary tangles and neuropil threads but al
COMMENT The article by Vogel and colleagues indicates the existence of four spatiotemporal patterns in Alzheimer’s disease (AD), with a prevalence ranging between 18-33 percent each. The elegance of the SuStaIn approach applied here lies in the fact that these fi
COMMENT Boon et al. describe a novel type of amyloid plaque that is specifically seen in early onset Alzheimer’s disease (AD) cases who have apolipoprotein (APOE) ε4/4 status (Boon et al., 2020). The association of these plaques with capillary cerebral amyloid an
COMMENT Since the Strittmatter group described the interaction between cellular prion protein (PrP C) and Aβ oligomers (Laurén et al., 2009), PrP C has been suggested as a mediator of functional and toxic deficits in Alzheimer’s disease. Later papers have extende
COMMENT Over the last decade, the RIPK1 protein has been studied intensively. This multifunctional kinase has been shown to play an important role in several signalling pathways underpinning energy homeostasis, inflammatory response, and cell death. Therefore, RI
COMMENT During the last years, we have seen growing evidence that cooperation between pathological proteins may be a key element in the pathogenesis of a variety of neurodegenerative diseases, with the most recent example being a study showing accelerated spreadi
COMMENT A third dimension of brain research? Liebmann et al. used the iDISCO clearing methods to stain amyloid plaques immunohistochemically as well as with staining dyes (Congo red, thioflavin s) to assess their three-dimensional structure. Compared to the class