5 RESULTS
COMMENT Although dementia with Lewy bodies (DLB) is the second-most-common cause of dementia, research into the underlying pathophysiology lags behind Alzheimer’s and Parkinson’s disease. Guerreiro and colleagues recently conducted the first large-scale genome-wi
COMMENT Reply to comment by Emory Hill The AD8 was designed as an informant assessment to screen for the
COMMENT There has been, for obvious reasons, a tremendous research effort investigating the role of tau protein and synuclein protein as the building blocks for filaments in neruofibrillary tangles, Lewy bodies and glial cytoplasmic inclusions. However, it is nic
COMMENT The study of Lewy body disorders will be greatly advanced with the development and characterization of transgenic mouse models. Although most lines overexpress alpha-synuclein, not all lines have necessarily recapitulated LB-like pathology. It is also unf
COMMENT "A model, a model...my kingdom for a model!" At last, a model that appears to recapitulate not only some of the motor features of Parkinson's disease, but also the pathology. Even as we have come to understand the importance of α-synuclein
