Charlie Arber, Selina Wray on Caught in the Act: Cryo-EM Exposes γ-Secretase Catalytic Pose
COMMENT Guo and colleagues advance our understanding of the biochemical processes behind γ-secretase-mediated cleavage of APP. Using cryo-EM of γ-secretase bound to APP-C99, Aβ49, Aβ46, and Aβ43, we are presented with the greatest insight yet of the sequential ge