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Morgan Sheng on Do Synaptic Markers Foreshadow Cognitive Decline?

COMMENT Overall, this study is an important advance in molecular biomarkers for Alzheimer’s disease. I am impressed by the robustness of the YWHAG:NPTX2 ratio in the CSF and how quantitative it is as a biomarker of cognitive impairment, independent of tau/Aβ meas

Morgan Sheng


The Broad Institute of MIT and Harvard
United States

Tau-PET and P-tau217—Equally Predictive, Yet Complementary

RESEARCH NEWS 2025-04-05 Research News Positive signals in tau PET scans and p-tau217 assays both suggest cognitive decline. Which performs better? Neither, according to a study published March 28 in Nature Aging—at least in people who are cognitively normal. Scientists led by Ri

Do Synaptic Markers Foreshadow Cognitive Decline?

RESEARCH NEWS 2025-04-04 Research News Markers in the cerebrospinal fluid can help clinicians identify who has the amyloid and tangle pathologies of Alzheimer’s disease. However, no CSF marker has been found to track well with cognitive decline. A new candidate may help. On March

Postdoctoral Fellow – Neurodegenerative Disease

JOB 2025-04-04 Employer UC San Diego Principal Investigator Christina Sigurdson Contact To Apply: Please send curriculum vitae and contact information for three references to: Christina Sigurdson, D.V.M., Ph.D., Dept. of Pathology, UCSD, 9500 Gilman Drive, La Jolla, CA

Neurodegeneration Postdoctoral Research Associate

JOB 2025-04-04 Employer University of Colorado, Boulder Principal Investigator Charles Hoeffer Contact Please direct questions to Charles Hoeffer  (Charles.hoeffer@colorado.edu) or Dr. Chris Link (linkc@colorado.edu). Information about the Department of Integrative Phys

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