Jobs
Postdoctoral Fellow – Neurodegenerative Disease
Posted 04 Apr 2025
Employer
UC San Diego
Location
San Diego, California
Principal Investigator
Contact
To Apply: Please send curriculum vitae and contact information for three references to: Christina Sigurdson , D.V.M., Ph.D., Dept. of Pathology, UCSD, 9500 Gilman Drive, La Jolla, CA 92093-0612; e-mail: csigurdson@ucsd.edu.
Description
The Neurodegenerative Disease Research Laboratory at UC San Diego is recruiting a postdoctoral researcher to join its team dedicated to unravelling the mechanisms of neurotoxicity in prion and Alzheimer's disease.
The lab uses iPSC-derived human neurons, primary mouse neurons, state-of-the-art molecular and biochemistry techniques, gene therapy, and knock-in mouse models to investigate the molecular basis for neuronal degeneration, with a focus on the endo-lysosomal pathway, autophagy, and synaptic excitotoxicity. It also studies how protein aggregates spread from cell to cell within the brain. They are looking for highly motivated candidates to lead projects including the impact of intracellular prions on endolysosomal function and neurotoxicity.
The salary is above NIH scale and the benefits are excellent.
NIH-funded projects include understanding the mechanisms of prion spread between cells through the glymphatic pathway, selective neuronal vulnerability in prion disease, and mechanisms underlying neurotoxicity. The Sigurdson Laboratory is highly interactive with collaborators at UCLA, NIH, Linkoping University, Sweden, University of Hamburg, Germany, as well as locally at UCSD and at The Scripps Research Institute.
Additional information can be found at http://sigurdsonlab.ucsd.edu.
Requirements
Candidates with research experience in neuroscience, cell biology, biochemistry and/or molecular biology, mouse genetics, and excellent communication skills are encouraged to apply. The successful candidates will conduct both independent and collaborative research within a productive scientific lab group. The candidates are also encouraged to explore new research areas and seek independent funding as part of their own career development.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or disability.