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RESEARCH NEWS 2024-07-14 Research News Microglia respond to proteinopathies by changing their shapes and expression profiles in different ways. Here’s one that has been somewhat overlooked: rod-shaped microglia. These long, straight cells have been observed in several neurodegene
RESEARCH NEWS 2024-07-13 Research News Tau in the blood can identify people in the earliest stages of Alzheimer’s disease, but plasma markers for other tauopathies, not to mention TDP-43 proteinopathies, have been hard to come by. Now, suddenly it seems, the field may have both.
RESEARCH NEWS 2024-07-12 Research News The innate immune protein C1q seems to have a thing for neurons. Already implicated in synaptic pruning by microglia, now it is reported to also slow down protein production in neurons of the aging mouse brain. In the June 24 Cell, researche
RESEARCH NEWS 2024-07-05 Research News In recent years, cryo-electron microscopists have unveiled a dazzling array of amyloid filament structures that underlie neurodegenerative diseases. Until now, all of them included but a single protein—Aβ, tau, α-synuclein, TDP-43, and other
COMMUNITY NEWS 2024-07-03 Community News Donanemab has become the second anti-amyloid immunotherapy to win traditional approval from the U.S. Food and Drug Administration. The antibody, which will be marketed as Kisunla, got the official go-ahead July 2. The decision had been wide
RESEARCH NEWS 2024-07-03 Research News The current tau PET tracers bind best to the fibrils found in Alzheimer’s disease, and now, finally, comes progress on non-AD tauopathies. In the June 14 Nature Communications, researchers led by Neil Vasdev at the University of Toronto, in
RESEARCH NEWS 2024-06-30 Research News Aη, or A-eta, made an initial splash when scientists reported that these fragments of amyloid precursor protein—products of a heretofore unknown cleavage—dampen neural activity. But how? The story went quiet. Nine years later, comes a possib
RESEARCH NEWS 2024-06-28 Research News The idea that infiltrating T cells contribute to a neurodegenerative environment in aging and in Alzheimer’s disease has gotten another boost. In the June 27 Nature Neuroscience, scientists led by Mikael Simons, Technical University Munich,
RESEARCH NEWS 2024-06-28 Research News In diseases driven by dysfunctional microglia, could replacing them with healthy versions prevent, or even reverse, pathology? Yes, suggest two papers in the June 18 Neuron. Both describe how mice completely devoid of microglia develop astro
RESEARCH NEWS 2024-06-27 Research News When in the clutches of β-secretase, the amyloid precursor protein (APP) lives up to its name, churning out the starting material for Aβ peptides and all that comes from them. What if this whole fiasco could be avoided by keeping the two apa
RESEARCH NEWS 2024-06-21 Research News Mutations that douse expression of the progranulin protein underlie nearly a third of familial frontotemporal dementia cases. Could scientists simply replace what is missing? Multiple progranulin replacement therapies are vying to do just th
RESEARCH NEWS 2024-06-21 Research News Clinicians are in desperate need of fluid markers that can detect Parkinson’s disease at the earliest stages. Now, they may have a candidate. In the June 18 Nature Communications, scientists led by Brit Mollenhauer at University Medical Cent
COMMUNITY NEWS 2024-06-14 Community News After a favorable review from a Food and Drug Administration advisory committee, Eli Lilly’s donanemab appears poised for marketing approval in the U.S. (Jun 2024 news). Are clinics ready? While last year’s approval of lecanemab is helping
RESEARCH NEWS 2024-06-14 Research News In the decades after the World Trade Center collapse, people who cleaned up the rubble have developed post-traumatic stress disorder, lung problems, cancer, and cognitive impairment. They also seem to be at high risk for early onset dementia
RESEARCH NEWS 2024-06-13 Research News Crafting a PET tracer to detect α-synuclein deposits in the brain has been an uphill struggle. Now, scientists led by Hironobu Endo and Makoto Higuchi at the National Institutes for Quantum Science and Technology in Chiba, Japan, describe a
