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Human Amyloid Imaging 2025

CONFERENCE COVERAGE SERIES At Human Amyloid Imaging Conference, Plasma Tau Was the Star When Tau Wanders Off, Subcortical Axon Firing Goes Mum Studying Diverse Populations May Require New Biomarkers After 14 years in Miami, HAI is on the move again. This January conference started

Yanaika Hok-A-Hin on Proteomics Lays Groundwork for FTD Biomarkers

COMMENT This study makes a valuable contribution to the search for fluid biomarkers in FTD. By investigating the CSF proteome in the well-characterized GENFI cohort, the authors analyzed a large group of presymptomatic and symptomatic carriers of mutations relate

Dave Morgan on New Biomarkers Catch Tau Before It Tangles

COMMENT This work is a tour de force, with a series of well-planned studies examining soluble tau assemblies (STAs) using a FRET assay in which both components are the same antibody, although the exact antibody used is not clear from the manuscript. The authors d

Stephen Salloway on New Biomarkers Catch Tau Before It Tangles

COMMENT This contains encouraging findings about the identification of phosphotau species that may correlate with pretangles and be a marker of risk for progression of AD-related cognitive decline. If replicated and expanded, these findings could provide importan

Bernard Hanseeuw on New Biomarkers Catch Tau Before It Tangles

COMMENT This beautiful work uses human brain samples, particularly the FRET assay showing that there are soluble tau oligomers, named “soluble tau assemblies.” It is puzzling to see that these STAs are AD specific! For the CSF analyses, I am less convinced of the

Khalid Iqbal on New Biomarkers Catch Tau Before It Tangles

COMMENT Tau pathology in humans or animals, without fail, is made up of the hyperphosphorylated protein. In AD tau is hyperphosphorylated sub-stoichiometrically at multiple sites by several combinations of protein kinases. Six isoforms of tau in the human brain a

At Human Amyloid Imaging Conference, Plasma Tau Was the Star

CONFERENCE COVERAGE 2025-02-14 Conference Coverage The hunt for blood-based biomarkers is continuing apace. At the Human Amyloid Imaging (HAI) meeting, held January 15-17, researchers focused on new techniques—all based on tau and blood, conference title notwithstanding—for identifying

New Biomarkers Catch Tau Before It Tangles

RESEARCH NEWS 2025-02-14 Research News Detecting toxic forms of tau before they weave into dense thickets of tangles could pave the way for earlier diagnosis and treatment of tauopathies, including Alzheimer’s disease. In the February 10 Nature Medicine, researchers led by Thomas

Does CSF Aβ Reflect Protofibril Concentration, Rather Than Plaques?

RESEARCH NEWS 2025-02-14 Research News In the Alzheimer’s field, conventional wisdom holds that the growth of amyloid plaques in the brain soaks up Aβ42 peptide, depleting it from cerebrospinal fluid. Now, in the February 12 Nature Aging online, scientists led by Oskar Hansson at

Seong Kang on New Biomarkers Catch Tau Before It Tangles

COMMENT This study represents a significant step forward in understanding early tau pathology and advancing biomarker development for AD. The identification of phosphorylation at serine-262 and serine-356 within the soluble tau assembly (STA) core (~tau258–368) p

Kanta Horie on New Biomarkers Catch Tau Before It Tangles

COMMENT This study is impactful because soluble tau assemblies (STA) containing phospho-tau serine-262 and phospho-tau-serine-356 were identified as components of pre-tangles, which are precursors of insoluble neurofibrillary tangles. From previous Cryo-EM experi

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