After 14 years in Miami, HAI is on the move again. This January conference started in chilly Boston and moved around the north for some time, meeting in Chicago, Seattle, and Toronto, before settling in a warmer clime in 2011. For 2025, HAI pulled up stakes again and landed in San Juan, Puerto Rico. There, 419 attendees from 16 countries shared data about how to line up blood biomarkers with PET data, how locus coeruleus connectivity might influence tangle spread, and what the field is learning from its growing focus on studying non-white populations.