340317 RESULTS
COMMENT Saido's team (Iwata et al.) infused labeled Aβ1-42 into rat hippocampus and found it was metabolized with a half-life of 39 minutes. They tried many classes of peptide inhibitors and found that neprilysin type were the only ones that prevented the br
COMMENT The data in the paper by Sigurdsson et al. are convinced that the immunization protocol they used is effective in decreasing plaque burden in the Tg2576 (also called APPsw) mouse model of AD. They present nice evidence that the peptide with which they imm
COMMENT α-Synuclein and β-amyloid: A Linking of Partners to Model Disease Creating transgenic models of neurodegenerative disease has yielded mixed results. The transgenic models of Huntington's chorea and amyotrophic lateral sclerosis have yielded animal mo
COMMENT Comment by Mark Gluck, Kin Ho Chan, M. Todd Allen Although these results are intriguing, the authors' interpretation of them seems to go beyond what the data actually might support. Briefly, the pattern of results they report is that as you look at a
COMMENT I liked the paper very much. It is generally well done and suggests an easy intervention that could reduce AD onset or progression without significant toxicity. Among the questions it raises are: 1.) How does the concentration of curcumin that is effectiv
COMMENT Mauch et al., in a well-designed, interesting study, demonstrate the importance of cholesterol to the formation of electrically functional synapses in cultured retinal ganglion cells. They demonstrate that retinal ganglion cells attain their normal morpho
COMMENT The compelling data by Mauch et al. affirms the critical nature of cholesterol in the CNS, particularly the developing CNS. As with most very good research, the experiments lead to important answers and provide the foundation for more questions. These aut
COMMENT This news report does not mention that the serine protease at the centre of the urokinase-plasminogen activator system, namely plasmin, is selective for Aβ 42 and in cleaving Aβ 42 prevents its aggregation into β-pleated sheet structures (see Exley and Ko
COMMENT Aβ-degrading enzymes—many candidates, but few fit the bill This comment extends the news report filed directly from the meeting to provide a more detailed description of this emerging area. To date, a number of potential Aβ-degrading enzymes have been ide
COMMENT This careful study rigorously tests a creative concept. We have also detected BACE and APP, though not PS-1, in the same subcellular compartment in AD neurons. That APP, BACE and PS1 are colocalized at the same subcellular site in axons is intriguing and
COMMENT Despite intensive study the functions of APP are unknown, however an increasing number of experiments are identifying functions of APP. This paper is interesting because it identifies a function that appears to be dependent on APP which, if true, would be
COMMENT These results are an important confirmation of findings previously reported. The authors were appropriately cautious in pointing out potential limitations to the interpretation of this study, including a potential ability of more highly educated people to
COMMENT This report is relevant both from the perspectives of pathogenesis (i.e., does chaperone activity alter susceptibility to PD ?) and potential avenue for therapeutic intervention (i.e., could increasing chaperone Hsp70 activity confer neuroprotection of af
COMMENT This is one of the few studies that have longitudinally explored the relation between leisure activities and dementia. The authors carefully tested the hypothesis that leisure activities contribute to the reserve against dementia by reserving a set of ski
COMMENT The Takashima mice are remarkable, as they appear to express high levels of the mutant tau protein in only a very few cells in the brain: that is, in some of the pyramidal cells of the hippocampus. Apparently the transgene is expressed at only very low le
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