339215 RESULTS
COMMENT This report is relevant both from the perspectives of pathogenesis (i.e., does chaperone activity alter susceptibility to PD ?) and potential avenue for therapeutic intervention (i.e., could increasing chaperone Hsp70 activity confer neuroprotection of af
RESEARCH NEWS 2001-12-21 Research News In 1999, Warrick et al. showed that the molecular chaperone Hsp70 could suppress neurodegeneration mediated by polyQ expansions in a protein associated with spinocerebellar ataxia. Now research from the same laboratory, directed by Nancy Bon
RESEARCH NEWS 2001-12-19 Research News Just in time to ponder this weighty question comes a short communication in tomorrow's Nature. Martin Carrier and colleagues at the William Harvey Research Institute in London report that polyphenols in red wines potently inhibit expres
COMMENT These results are an important confirmation of findings previously reported. The authors were appropriately cautious in pointing out potential limitations to the interpretation of this study, including a potential ability of more highly educated people to
RESEARCH NEWS 2001-12-14 Research News See also live discussion on this topic. The Science Fiction channel occasionally runs a marathon of "Twilight Zone:" Back-to-back episodes all day long, each one related to the other through novel scripts with interesting ideas tha
RESEARCH NEWS 2001-12-14 Research News A study of the elderly in Sweden provides more evidence that people with a higher level of education are less likely to be diagnosed with Alzheimer's disease or other dementias. The article, by Chengxuan Qui and collegues at the Karolin
COMMENT Despite intensive study the functions of APP are unknown, however an increasing number of experiments are identifying functions of APP. This paper is interesting because it identifies a function that appears to be dependent on APP which, if true, would be
COMMENT This careful study rigorously tests a creative concept. We have also detected BACE and APP, though not PS-1, in the same subcellular compartment in AD neurons. That APP, BACE and PS1 are colocalized at the same subcellular site in axons is intriguing and
RESEARCH NEWS 2001-12-11 Research News In last Friday's Nature, Lawrence Goldstein of the University of California, San Diego, further advanced his claim that the amyloid-β precursor protein (AβPP) mediates fast, anterograde axonal transport by binding to the motor protein k
WEBINAR 2001-12-11 Keith Crutcher led this live discussion on 11 December 2001. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held on 11 December 2001. Participants: Keith Crutcher, Nico S
CONFERENCE COVERAGE SERIES CNDR 2nd Annual Retreat: Welcome and Introduction CNDR 2nd Annual Retreat: Amyloid-binding Ligands as AD Therapies CNDR 2nd Annual Retreat: Gonadal Hormones Control β-Amyloid in Vivo CNDR 2nd Annual Retreat: Metal Complexing Agents as Therapies for AD CND
RESEARCH NEWS 2001-12-07 Research News The discovery of newly born neurons in the adult primate neocortex caused a great stir two years ago, opening, as it seemed, one of the most promising avenues of research into replacing neurons destroyed by neurodegenerative disease. Writing
CONFERENCE COVERAGE 2001-12-07 Conference Coverage According to Ashley Bush of Harvard Medical School, Aβ is rapidly precipitated by Zn2+ at low physiological concentrations, and Cu2+ and Fe3+ also induce Aβ aggregation. Zn/Cu-selective chelators markedly enhance the solubilization of
RESEARCH NEWS 2001-12-07 Research News The therapeutic potential of human stem cells seems a little more realistic, thanks to results published in this month's Nature Biotechnology. Two groups have succeeded in transplanting human neural progenitors into neonatal mice. From
RESEARCH NEWS 2001-12-07 Research News In the last four years, cancer researchers have come to realize that the lipid phosphatase PTEN is perhaps as important a tumor suppressor as its more famous cousin p53. At the same time, other researchers are trying to harness the almost-my
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