PAPER Jiménez JL, Guijarro JI, Orlova E, Zurdo J, Dobson CM, Sunde M, Saibil HR
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PAPER Savolainen KM, Loikkanen J, Eerikäinen S, Naarala J
Interactions of excitatory neurotransmitters and xenobiotics in excitotoxicity and oxidative stress: glutamate and lead.
Toxicol Lett. 1998 Dec 28;102-103:363-7. PubMed.PAPER Tringali G, Dello Russo C, Preziosi P, Navarra P
Hypothalamic interleukin-1 in physiology and pathology.
Toxicol Lett. 1998 Dec 28;102-103:295-9. PubMed.PAPER Scott WK, Grubber JM, Abou-Donia SM, Church TD, Saunders AM, Roses AD, Pericak-Vance MA, Conneally PM, Small GW, Haines JL
Further evidence linking late-onset Alzheimer disease with chromosome 12.
JAMA. 1999 Feb 10;281(6):513-4. PubMed.Can Vitamin C Smuggle Drugs Through the Blood-Brain Barrier?
RESEARCH NEWS 2002-01-23 Research News In the upcoming print issue of the Journal of Medicinal Chemistry, Italian researchers led by Allesandro Dalpiaz are reporting initial success in using Vitamin C to ferry drugs through the blood-brain barrier, an obstacle in the development
Human Aβ Vaccine Snagged by CNS Inflammation
RESEARCH NEWS 2002-01-23 Research News Elan Corporation announced last Thursday that it would temporarily suspend further drug administration in the clinical phase 2A trial of its therapeutic vaccine AN-1792, made of synthetic Aβ1-42 peptide. Four patients have fallen ill with wh
Alberto Lleó on Hemochromatosis as a Factor in AD
COMMENT I have read with interest the comment on HFE mutations and AD. Our group also postulated that a genetic defect in iron metabolism could be associated with a greater risk for AD. Therefore, we analyzed the two common HFE mutations and the Transferrin C2 al
Hemochromatosis as a Factor in AD
WEBINAR 2002-01-22 Liz Milward led this live discussion on 22 January 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Summary of Live Discussion Comments Maire Percy and Theo Kruck Hyman M. Schipper Participant
The Problem with Interleukin-6
RESEARCH NEWS 2002-01-21 Research News Since it became clear that Alzheimer's disease has features in common with chronic inflammation, much effort has gone into determining whether the various inflammatory response molecules are helping to protect, or to destroy, vulnerable
Richard Bowen on Urocortin Is Potent Protector of Hippocampal Neurons
COMMENT The observation that, in vitro, urocortin provides neuroprotection to vulnerable neurons may have some therapeutic implications in Alzheimer's disease (AD). However, these implications are not clear-cut, since other studies have shown that administer
Daniel Watterson on Targeting Glial Cells—Towards Selective, CNS-Specific Antiinflammatory Drugs
COMMENT Author's Response We read with interest the comments of Mark Smith and George Perry, which raise interesting philosophical points but do not directly address the results in our recent paper. In our peer-reviewed report, we describe a new class of syn
Protein-Protein Interactions, Cytoskeleton Implicated in Huntington's
RESEARCH NEWS 2002-01-18 Research News Huntington's disease (HD) is caused by polyglutamine (polyQ) expansion within the huntingtin protein (Htt), but the sequence of events leading to neurodegeneration remains unclear. Recent evidence has moved the spotlight away from the r
Urocortin Is Potent Protector of Hippocampal Neurons
RESEARCH NEWS 2002-01-18 Research News Low concentrations of the hormone urocortin protects cultured hippocampal neurons from a number of toxic agents, including Aβ, according to an article in the current Journal of Neuroscience. Mark Mattson and colleagues at the National Instit
Michael Schlossmacher on Picking up the Pieces of Parkin
COMMENT Three principal issues arise from the literature reviewed by Dr. Wolozin and his comments: (1) an evolving concept that previously separated forms of parkinsonism actually present heterogeneity of one and the same Parkinson's disease (PD) syndrome; (
Picking up the Pieces of Parkin
WEBINAR 2002-01-17 Benjamin Wolozin led this live discussion on 17 January 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held on 17 January 2002. Participants: Benjamin Wolozin, Mich
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