339239 RESULTS
RESEARCH NEWS 2002-01-10 Research News Transgenic mice have become a staple in the study of basic biology and disease, including Alzheimer's. Even so, the method predominantly used today to create these animals remains technically difficult, costly, and impractical in other
COMMENT Homeostatic Control: Relevance to Alzheimer Disease Larsen and Clarke highlight that endogenous homeostatic control over energetics and endogenous antioxidant defenses make cells and organisms better adapted to survival than exogenous intervention. These
COMMENT I find the study interesting because our work suggests that SIR2 will be a universal regulator of aging (definitely in yeast and worms) and we recently found that it functions as a negative regulator of p53 in mammalian cells. My hunch is that this is onl
COMMENT Reply by Akihiko Takashima Regarding Peter Davies' comment, I would like to reply. We observed human tau expression in the entire brain where the PDGF promoter activates. In the hippocampus region, exogenously expressing human tau is highly accumulat
COMMENT The Takashima mice are remarkable, as they appear to express high levels of the mutant tau protein in only a very few cells in the brain: that is, in some of the pyramidal cells of the hippocampus. Apparently the transgene is expressed at only very low le
RESEARCH NEWS 2002-01-07 Research News P53 misregulation and cancer have become almost synonymous in the scientist's imagination. Mutations in this prominent tumor suppressor gene have been found in the majority of human cancers, and downregulating the protein increases tumo
COMMENT This is one of the few studies that have longitudinally explored the relation between leisure activities and dementia. The authors carefully tested the hypothesis that leisure activities contribute to the reserve against dementia by reserving a set of ski
RESEARCH NEWS 2002-01-04 Research News A study in last month's Neurology provides more evidence that people who engage in little leisure activity are at greater risk for developing Alzheimer's disease. The study, by Yaakov Stern et al. at Columbia University, New York,
RESEARCH NEWS 2002-01-04 Research News The question of how neurofibrillary tangles (NFTs) contribute to the profound loss of neurons in Alzheimer's disease remains unsettled in part because of a dearth of suitable animal models. A handful of transgenic mouse strains exist th
COMMENT This report is relevant both from the perspectives of pathogenesis (i.e., does chaperone activity alter susceptibility to PD ?) and potential avenue for therapeutic intervention (i.e., could increasing chaperone Hsp70 activity confer neuroprotection of af
RESEARCH NEWS 2001-12-21 Research News In 1999, Warrick et al. showed that the molecular chaperone Hsp70 could suppress neurodegeneration mediated by polyQ expansions in a protein associated with spinocerebellar ataxia. Now research from the same laboratory, directed by Nancy Bon
RESEARCH NEWS 2001-12-19 Research News Just in time to ponder this weighty question comes a short communication in tomorrow's Nature. Martin Carrier and colleagues at the William Harvey Research Institute in London report that polyphenols in red wines potently inhibit expres
COMMENT These results are an important confirmation of findings previously reported. The authors were appropriately cautious in pointing out potential limitations to the interpretation of this study, including a potential ability of more highly educated people to
RESEARCH NEWS 2001-12-14 Research News See also live discussion on this topic. The Science Fiction channel occasionally runs a marathon of "Twilight Zone:" Back-to-back episodes all day long, each one related to the other through novel scripts with interesting ideas tha
RESEARCH NEWS 2001-12-14 Research News A study of the elderly in Sweden provides more evidence that people with a higher level of education are less likely to be diagnosed with Alzheimer's disease or other dementias. The article, by Chengxuan Qui and collegues at the Karolin
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