339239 RESULTS
COMMENT Despite intensive study the functions of APP are unknown, however an increasing number of experiments are identifying functions of APP. This paper is interesting because it identifies a function that appears to be dependent on APP which, if true, would be
COMMENT This careful study rigorously tests a creative concept. We have also detected BACE and APP, though not PS-1, in the same subcellular compartment in AD neurons. That APP, BACE and PS1 are colocalized at the same subcellular site in axons is intriguing and
RESEARCH NEWS 2001-12-11 Research News In last Friday's Nature, Lawrence Goldstein of the University of California, San Diego, further advanced his claim that the amyloid-β precursor protein (AβPP) mediates fast, anterograde axonal transport by binding to the motor protein k
WEBINAR 2001-12-11 Keith Crutcher led this live discussion on 11 December 2001. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held on 11 December 2001. Participants: Keith Crutcher, Nico S
CONFERENCE COVERAGE SERIES CNDR 2nd Annual Retreat: Welcome and Introduction CNDR 2nd Annual Retreat: Amyloid-binding Ligands as AD Therapies CNDR 2nd Annual Retreat: Gonadal Hormones Control β-Amyloid in Vivo CNDR 2nd Annual Retreat: Metal Complexing Agents as Therapies for AD CND
RESEARCH NEWS 2001-12-07 Research News The discovery of newly born neurons in the adult primate neocortex caused a great stir two years ago, opening, as it seemed, one of the most promising avenues of research into replacing neurons destroyed by neurodegenerative disease. Writing
CONFERENCE COVERAGE 2001-12-07 Conference Coverage According to Ashley Bush of Harvard Medical School, Aβ is rapidly precipitated by Zn2+ at low physiological concentrations, and Cu2+ and Fe3+ also induce Aβ aggregation. Zn/Cu-selective chelators markedly enhance the solubilization of
RESEARCH NEWS 2001-12-07 Research News The therapeutic potential of human stem cells seems a little more realistic, thanks to results published in this month's Nature Biotechnology. Two groups have succeeded in transplanting human neural progenitors into neonatal mice. From
RESEARCH NEWS 2001-12-07 Research News In the last four years, cancer researchers have come to realize that the lipid phosphatase PTEN is perhaps as important a tumor suppressor as its more famous cousin p53. At the same time, other researchers are trying to harness the almost-my
CONFERENCE COVERAGE 2001-12-07 Conference Coverage The Center for Neurodegenerative Disease Research (CNDR) at the University of Pennsylvania School of Medicine organized the 2nd Annual CNDR Retreat as a one day symposium entitled "Emerging Alzheimer's Disease Therapies: Focu
CONFERENCE COVERAGE 2001-12-07 Conference Coverage Ivan Lieberburg of Elan Corporation summarized evidence over the past 15 years supporting the role of amyloid as causal in the onset and/or progression of AD. Aβ, a 42 amino acid long peptide derived the amyloid precursor protein (APP)
RESEARCH NEWS 2001-12-07 Research News Cynthia Lemere of Harvard Medical School summarized the efforts and progress of her group to develop intranasal immunotherapy for AD in transgenic mouse models of AD-like amyloidosis by delivering the human Aβ peptides through the nasal rout
CONFERENCE COVERAGE 2001-12-07 Conference Coverage Due to the illness of Blas Frangione, New York University School of Medicine, E. M. Sigurdsson, gave this presentation on another alternative for immunotherapy of AD. Dr. Sigurdsson reviewed recent studies of transgenic mice with AD-li
CONFERENCE COVERAGE 2001-12-07 Conference Coverage Dr. Samuel Gandy of Thomas Jefferson Medical School began his presentation by stating that since 1990, 14 of 15 epidemiological studies reported that hormone replacement therapy (HRT) reduced the relative risk of AD in postmenopausal w
CONFERENCE COVERAGE 2001-12-07 Conference Coverage Virginia M.-Y. Lee, University of Pennsylvania School of Medicine, summarized studies conducted by investigators in CNDR in collaboration with the Kung lAβ at Penn that seek to identify new therapies for AD, and the therapeutic targets
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