The Antibodies database was archived in December 2022 and is no longer being updated. The Antibodies database is being supplanted by the AlzAntibodies database, which aims to provide detailed descriptions of selected antibodies.

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Antibodies

29333 Results

Name Source Clonality &
Isotype		 Host &
Formulation		 Method Reactivity Immunogen/
Epitope		 Specificity Availability
APP, APLP, AICD From manufacturers (8)
Abcam polyclonal
IgG		 Rabbit
(liquid, whole antiserum, azide)		 - Human, Macaque immunogen = synthetic peptide (S E Q E T G P C R A M I S R W Y F D T) corr. to aa 292-312 of the KPI domain of human APP recognises an epitope in the Kunitz protease inhibitor (KPI) domain of human APP -
Abcam polyclonal
IgG		 Goat
(liquid, whole serum, thimerosal)		 - Human immunogen = synthetic peptide: H M N V Q N G K W D S D P S G T K T C I, corresp. to N-terminal aa44-63 of human Amyloid Precursor Protein recognizes APP Frameshift Mutant (APPFM). -
Abcam polyclonal
IgG		 Rabbit
(liquid, PBS, azide, protein G purified)		 - Human, Mouse immunogen = synthetic peptide from the N-terminal region of human Amyloid Precursor Protein, conjugated to KLH detects APP -
Abcam monoclonal
IgG1		 Mouse
(liquid, PBS, no preservative, protein A purified)		 - Human immunogen = synthetic peptide amyloid precursor protein. Epitope lies within aa61-77 of amyloid precursor protein APP -
Abcam monoclonal
IgG1, κ		 Mouse
(liquid, Tris-HCl, azide, diluted)		 - Dog, Rabbit, Cow, Sheep, Pig, Chimpanzee, Human, Monkey, Guinea Pig, Cynomolgus immunogen = synthetic peptide: S G Y E V H H Q K L, corresp. to aa660-669 of human Amyloid Precursor Protein (which is the same as amino acids 8-17 of the mature Amyloid Protein) APP -
Abcam monoclonal
IgM		 Mouse
(liquid, supernatant, azide)		 - Human immunogen = prokaryotic recombinant fusion protein corresp. to the extracellular protein of APP between the Kunitz protease inhibitor domain and the beta amyloid region. APP; no crossreaction with APP-like proteins is evident -
Abcam monoclonal
IgM		 Mouse
(liquid, supernatant, azide)		 - Human immunogen = prokaryotic recombinant fusion protein corresp. to the extracellular protein of APP between the Kunitz protease inhibitor domain and the beta amyloid region. APP; no crossreaction with APP-like proteins is evident -
Abcam monoclonal
IgG2a, κ		 Mouse
(liquid, PBS, azide, protein A purified)		 - Human immunogen = secretory amyloid precursor protein secreted by the EJ-1 bladder carcinoma cell line reacts with Secretory Amyloid Precursor Protein (sAPP), but not with Amyloid-Beta protein 1-40. -
Amyloid-β From labs (3)
anti-Aβ38(Pankaj Mehta,Department of Immunology, New York State Institute for Basic Research, Staten Island, New York)Paper: Potempska A, Mack K, Mehta PD, et al. Quantitation of sub-femtomole amounts of Alzheimer amyloid beta peptides. Amyloid: Int J Clin Invest 1999;16:14-21 kit
 Unknown Host
(Sandwich ELISAmonoclonal antibody 6E10 (Signet Labs) is used as capture antibodyrabbit antiserum to Aβ38 is used as the detection antibody)		 - Human immunogen (detection antibody) = peptide hCys-aminohexoanoyl-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-GlyOH detects amyloid-beta 38; no reaction to Aβ40 or Aβ42 -
αAβC40J. Buxbaum, Mt. Sinai School of Medicine, NewYork, NYPaperReferences:Hashimoto, 2010Lord, 2009Näslund, 2000 polyclonal
 Rabbit
(serum)		 - Human, Mouse immunogen = peptide corresponding to the 6 Cterminalresidues of Abx-40 and containing N-terminal cysteineresidues, coupled to KLH recognizes amyloid-beta x-40 -
αAβC42J. Buxbaum, Mt. Sinai School of Medicine, NewYork, NYPaperReferences:Hashimoto, 2010Lord, 2009Näslund, 2000 polyclonal
 Rabbit
(serum)		 - Human, Mouse immunogen = peptide corresponding to the 6 Cterminalresidues of Abx-42 and containing N-terminal cysteineresidues, coupled to KLH recognizes amyloid-beta x-42 -
Amyloid-β From manufacturers (14)
Chemicon and Upstate are Millipore monoclonal
IgG2a, κ		 Mouse
(liquid, Tris-glycine saline, azide, protein G purified)		 - Human, Mouse immunogen = human beta amyloid peptide (epitope at aa 4-10) recognizes amino acid residues 4-10 of human Amyloid β, can also show 120 and 105 kDa APP proteins, and ~45 kDa oligomers of amyloid proteins on our western blot of human Alzheimer diseased brain lysate -
Genetics Company, Inc. monoclonal
IgG2a,κ		 Mouse
(biotinylated supernatant IgG, stabilizing solution, no azide, affinity purified)		 - Human N-terminal: Epitope mapping corr. to amino acid residues 4-10 of human Aβ-peptide High affinity to Amyloid peptides Aβ 1-38, Aβ 1-39, Aβ 1-40, Aβ 1-43 and Aβ 1-44 -
Genetics Company, Inc. monoclonal
IgG2a,κ		 Mouse
(peroxidase, supernatant IgG, stabilizing solution, no azide, affinity purified)		 - Human N-terminal: Epitope mapping corr. to amino acid residues 4-10 of human Aβ-peptide High affinity to Amyloid peptides Aβ 1-38, Aβ 1-39, Aβ 1-40, Aβ 1-43 and Aβ 1-44 -
BioLegend monoclonal
IgG1		 Mouse
(liquid, no preservatives or carrier proteins, purified)		 - Human epitope lies within amino acids 1-8 of the β-Amyloid protein reacts to N-terminal aa 1-8 of β-Amyloid peptide and β-amyloid form of APP Available from BioLegend
Wako Chemicals kit
 Mouse
(96 tests:BAN50/BA27(Fab') antibodies from Takeda Chemical Industries.range: 1.0~100 pmol/L)		 - Human   Aβ (1-40); detects the N-terminal of Aβ -
Wako Chemicals kit
 Mouse
(96 tests:BAN50/BA27(Fab')2, HRP conj. antibodies from Takeda Chemical Industries.range: 1.0~100 pmol/L.Achieved stable antigen-antibody reaction)		 - Human achieves more stable antigen-antibody reactions by using F(ab' )2 fragment of the labeled antibody BA27, which recognizes the C-terminal of beta Amyloid 40, while the nonspecific binding is remaining to be reduced Aβ (1-40); detects the C-terminal -
Wako Chemicals kit
 Mouse
(96 tests:BAN50/BC05(Fab') HRP conj. antibodies from Takeda Chemical Industries.range: 1.0~100 pmol/L.)		 - Human   detects C-terminal of Aβ 42 -
Wako Chemicals monoclonal
 Mouse
(50 tests: This kit stains Aβ40 or Aβ42 in tissue section bythe monoclonal antibodies that detects the portionof Ｃ-terminal of Aβ.)		 - -   distinctive staining of Aβ(1-40) and Aβ(1-42) plaques -
Wako Chemicals kit
 Mouse
(96 tests:BNT77/BA27(Fab') HRP conj. antibodies from Takeda Chemical Industries.range: 1.0~100 pmol/L)		 - Human, Mouse, Rat BNT77: Specifically detects the Aβ (11-28) of AβBA27: Specifically detects the C-terminal of Aβ 40 detects Aβ (x-40), with a truncated or modified N-terminus -
None monoclonal
IgG1		 Mouse
(liquid, PBS, no preservatives or carrier proteins, purified, HRP conj.)		 - Human epitope = lies within aa 3-8 of the β-amyloid peptide (EFRHDS) reactive to aa 1-16 of β-Amyloid (precursor forms as well as abnormally processed isoforms Discontinued
Invitrogen Corporation polyclonal
 Rabbit
(liquid, affinity purified, rabbit polyclonal immunoglobulins in phosphate buffer, pH 7.4. Carrier and preservative free)		 - Human immunogen = synthetic peptide derived from amino acids 36-42 within the carboxyl-terminus region of human β-Amyloid protein Reacts with human Aβ42. No significant cross-reactivity to Aβ40 or Aβ43 has been observed -
Invitrogen Corporation polyclonal
 Rabbit
(liquid, affinity purified, rabbit polyclonal immunoglobulins in phosphate buffer, pH 7.4. Carrier and preservative free)		 - Human immunogen = synthetic peptide derived from amino acids 34-40 within the carboxyl-terminus region of human β-Amyloid protein Reacts with human Aβ40. No significant cross-reactivity to Aβ42 or Aβ43 has been observed -
Invitrogen Corporation polyclonal
 Rabbit
(liquid, affinity purified, rabbit polyclonal immunoglobulins in phosphate buffer, pH 7.4. Carrier and preservative free.Any reactivity to Aβ40 or Aβ42 eliminated through a series of preabsorption steps)		 - Human - Reacts with human Aβ43. No significant cross-reactivity to Aβ40 or Aβ42 -
Invitrogen Corporation polyclonal
 Rabbit
(liquid, affinity purified, PBS, azide.Any reactivity to Aβ40 or Aβ42 eliminated through a series of preabsorption steps.Biotin conj.)		 - Human, Mouse, Rat - Reacts with human Aβ42. No significant cross-reactivity to Aβ1-40 or Aβ1-43 has been observed -
Amyloid-β, APP, APLP, AICD From manufacturers (1)
BioLegend monoclonal
IgG2b		 Mouse
(biotinylated IgG, PBS, no preservatives or carrier proteins)		 - Human, Mouse the epitope lies within amino acids 18-22 of beta amyloid (VFFAE) reactive to aa 17-24 Aβ and to APP -
DNA Damage & Repair From manufacturers (9)
Calbiochem EMD Biosciences monoclonal
IgG1		 Mouse
(purified, PBS, BSA, azide)		 - Human, Monkey, Hamster, Mouse, Rat C-terminus of PARP DNA-binding domain of purified calf thymus PARP full length (115 kDa) PARP and the 85-90 kDa apoptosis-related cleavage fragment -
Calbiochem EMD Biosciences monoclonal
IgG		 Mouse
(liquid, undiluted ascites, azide)		 - Bovine, Human immunogen within the zinc finger II DNA-binding domain of purified calf thymus PARP zinc finger II domain with the full length ~116 kDa PARP, and the ~24 kDa cleavage fragment -
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(liquid, undiluted serum, azide)		 - Human immunogen = synthetic peptide (KQLPGVKSE GKRKGDEVD) corresponding to amino acids 197-214 of the human PARP protein detects uncleaved 110 kDa human PARP protein or the cleaved 29 kDa fragment -
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(liquid, undiluted serum, azide)		 - Human immunogen = synthetic peptide (GVDEVAKKKSKKEK) corresp. to aa 215-228 of the human PARP protein detects uncleaved 110 kDa human PARP protein or the cleaved 85 kDa fragment -
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(liquid, undiluted serum, azide)		 - Bovine, Human, Monkey, Hamster, Mouse, Rat immunogen = synthetic peptide (SKGPVKEEGTNKSEKR) corresponding to amino acids 509-524 of the bovine PARP protein automodification domain detects PARP protein -
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(liquid, undiluted serum, azide)		 - Bovine, Human, Monkey, Gerbil, Mouse, Rat immunogen = full-length PARP-1 protein purified from bovine thymus. detects PARP-1 protein -
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(purified, PBS, gelatin, azide)		 - Human immunogen = a synthetic peptide (SESSDKLY RVEYAKSG) corresp. to amino acids at the N-terminus of human PARP detects full-length (115 kDa) PARP and the 24-31 kDa apoptosis-related cleavage fragment -
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(liquid, undiluted serum, azide)		 - Human immunogen = Poly (ADP-Ribose) with methylated BSA detects polymers ranging in size from 2Ð300 pADPr units; some cross-reactivity with BSA (~67 kDa). -
Orbigen polyclonal
 Rabbit
(serum, affinity purified, PBS, azide)		 - Human   reacts with N-terminus of human PARP-1 -
Glutamate Receptor & Related From manufacturers (7)
Cell Signaling polyclonal
 Rabbit
(liquid, HEPES, NaCl, BSA, glycerol, Protein A affinity purified)		 - Human, Mouse, Rat Immunogen = a synthetic peptide corresp. to residues surrounding Ser720 of human GluR2 detects endogenous levels of total GluR 2/3/4 protein; may also detect GluR1 -
Cell Signaling polyclonal
 Rabbit
(liquid, Hepes, saline, BSA, glycerol, Protein A purified)		 - Human, Mouse, Rat Immunogen = a synthetic peptide corresponding to human NMDAR1 detects endogenous levels of total NMDAR1 protein -
Cell Signaling polyclonal
 Rabbit
(liquid, Hepes, saline, BSA, glycerol, affinity purified)		 - Mouse, Rat Immunogen = a synthetic peptide corresponding to human NMDAR2A detects endogenous levels of total NMDAR2A protein -
Cell Signaling polyclonal
 Rabbit
(liquid, HEPES, saline, BSA, glycerol, affinity purified)		 - Human, Mouse, Rat Immunogen = a synthetic peptide corresponding to human NMDAR2B detects endogenous levels of total NMDAR2B protein, 190 kDa by WB -
Cell Signaling polyclonal
 Rabbit
(liquid, Hepes, NaCl, BSA, glycerol, Protein A purified)		 - Human, Mouse, Rat Immunogen = synthetic phospho-peptide corresp. to the residues around Ser896 of human NMDAR1 Detects overexpressed NMDAR1 only when phosphorylated at serine 896 -
Cell Signaling polyclonal
 Rabbit
(liquid, Hepes, NaCl, BSA, glycerol, Protein A purified)		 - Human, Mouse, Rat Immunogen = synthetic phospho-peptide corresp. to residues around Ser897 of human NMDAR1 Detects overexpressed NMDAR1 only when phosphorylated at serine 897 -
Cell Signaling polyclonal
 Rabbit
(liquid, Hepes, NaCl, BSA, glycerol, Protein A purified)		 - Human, Mouse, Rat Immunogen = synthetic phospho-peptide corresponding to residues around serine 890 of human NMDAR1 Detects overexpressed and endogenous NMDAR1 only when phosphorylated at Ser890 -
Growth Factors From manufacturers (10)
Chemicon and Upstate are Millipore polyclonal
 Rabbit
(serum, lyophilized)		 - Human, Mouse, Rat immunogen = synthetic peptide from human proBDNF 35 kDa pro BDNF; does not cross-react with other pro neurotrophins -
LifeSpan Biosciences, Inc. monoclonal
 Mouse
(ion exchange chromatography)		 - Human immunogen = recombinant human BDNF BDNF -
LifeSpan Biosciences, Inc. polyclonal
 Rabbit
 - Human, Mouse, Rat - BDNF -
LifeSpan Biosciences, Inc. polyclonal
 Chicken
 - Human, Mouse immunogen = two synthetic peptides from human BDNF were mixed and used as immunogens BDNF -
Promega kit
 Unknown Host
(Emax® ImmunoAssay System, sandwich Elisa, mAb primary)		 - Human - BDNF -
Santa Cruz monoclonal
IgG1		 Mouse
(liquid, PBS, azide, protein stabilizer)		 - Human, Mouse, Rat immunogen = recombinantBDNF of human origin detects precursor and mature BDNF,and to a lesser extent, NGF -
Santa Cruz polyclonal
IgG		 Rabbit
(liquid, PBS, azide, gelatin.Available as agarose conjugate for IP, sc-20981 AC)		 - Human, Mouse, Rat immunogen = amino acids 130-247 at the C-terminus of BDNF of human origin detects precursor and mature BDNF,and to a lesser extent, NGF -
Santa Cruz polyclonal
IgG		 Rabbit
(affinity purified, PBS, azide, gelatin)		 - Cat, Dog, Pig, Human, Mouse, Rat mapping within an internal region of human BDNF detects precursor and mature BDNF,and to a lesser extent, NGF -
Biosensis polyclonal
 Rabbit
(serum, affinity purified, lyophilized)		 - Human, Mouse, Rat immunogen = synthetic peptide (C-ELLDED QKVRPNEE) as a part of human BDNF precursor protein (aa: 69-82) conjugated to KLH detects 35 kDa pro BDNF; does not cross-react with other pro neurotrophins -
Abcam polyclonal
IgG		 Rabbit
(liquid, whole antiserum, no preservative)		 - Human, Mouse, Rat immunogen = a peptide from the N-terminal region of mature mouse BDNF conjugated to a carrier protein to enhance immunological response recognizes both the mature BDNF and unprocessed precursor (proBDNF); shows no cross-reactivity with NGF, NT3 and NT4/5 using WB -
Heme Oxygenase & Peroxiredoxin From manufacturers (1)
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(IgG, purified, azide, gelatin, KLH-conj. lyophilized, control peptide)		 - Mouse, Rat immunogen = synthetic peptide corr. to aa 2-23 of rat HO-1 protein; two mismatches with the reported human and rat sequences. recombinant heme oxygenase-1 protein -
Immune Cells From manufacturers (2)
Hycult Biotechnology monoclonal
IgG1		 Mouse
(liquid, filtered, PBS, BSA, azide)		 - Human - detects both free LL37 and total hCAP18 -
Hycult Biotechnology monoclonal
IgG2a		 Mouse
(liquid, filtered, PBS, BSA, azide)		 - Human - can be used for Western blotting; detects both free LL37 and total hCAP18 -
NGF & Trk Receptors From manufacturers (13)
Chemicon and Upstate are Millipore monoclonal
IgG1		 Mouse
(purified, DEAE, azide, lyophilized)		 - Bovine, Human, Mouse, Rat immunogen = 2.5 S form of mouse NGF 2.5S and 7.0S NGF-β -
LifeSpan Biosciences, Inc. monoclonal
 Rat
 - Human - NGFβ -
Promega polyclonal
IgY		 Chicken
(liquid, saline, dipotassium phosphate, gentamicin)		 - Various animal, Human, Mouse immunogen = Human recombinant NT-3 highly specific for NT-3 -
Santa Cruz polyclonal
IgG		 Rabbit
(affinity purified, PBS, azide, gelatin)		 - Human, Mouse, Rat mapping within an internal region of human NGF detection of NGF precursor (13 kDa) and mature forms (27 kDa) -
Calbiochem EMD Biosciences monoclonal
IgG1		 Mouse
(affinity purified, lyophilized)		 - Human, Rat purified human recombinant β-NGF. β-NGF, notrecombinant BDNF or NT-3  -
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(liquid, sodium phosphate buffer, gelatin azide)		 - Primate (various), Human, Rat immunogen = synthetic peptide (ALANAPPYYLDVLG) corresponding to amino acids 777-790 within the C-terminal domain of human c-Trk p140/110 trk A proto-oncogene, and moderately with trk B -
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(liquid, sodium phosphate buffer, gelatin, azide)		 - Human, Rat immunogen = a synthetic peptide corresponding to amino acids 807-822 of human TrkB detects TrkB -
Calbiochem EMD Biosciences polyclonal
IgG		 Rabbit
(liquid, HEPES, saline, glycerol)		 - Human, Rat immunogen = a synthetic phosphopeptide (IENPQpYFSD) corresponding to amino acids 485-493 surrounding the Tyr490 phosphorylation site of human TrkA detects trk only when activated by phosphorylation at Tyr490 -
Calbiochem EMD Biosciences monoclonal
IgG1<?sub ??>		 Mouse
(liquid, PBS, gelatin, azide)		 - Rat immunogen = soluble protein from PC12 cell membranes recognizes the ~75 kDa NGF-receptor protein in PC12 cells -
Cell Signaling polyclonal
 Rabbit
(liquid, protein-A purified, HEPES, saline, BSA, glycerol)		 - Human immunogen = a synthetic peptide corresponding to human TrkB detects transfected levels of total TrkB protein, 145 kDa by WB -
Cell Signaling monoclonal
IgG		 Rabbit
(liquid, HEPES, saline, BSA, glycerol, azide)		 - Human, Mouse, Rat immunogen = a synthetic peptide (KLH-coupled) surrounding Pro50 of human TrkB detects endogenous levels of total TrkB protein; does not cross-react with TrkA -
Cell Signaling monoclonal
IgG		 Rabbit
(liquid, HEPES, saline, BSA, glycerol, azide)		 - Human immunogen = a synthetic peptide (KLH-coupled) surrounding Pro50 of human TrkB detects endogenous levels of total TrkB protein; does not cross-react with TrkA -
Cell Signaling monoclonal
IgG		 Rabbit
(liquid, HEPES, saline, BSA, glycerol, azide)		 - Human immunogen = a synthetic phosphopeptide(KLH-coupled) surrounding Arg220 of human TrkA recognizes endogenous levels of total TrkA protein; does not cross-react with TrkB -
Neural Progenitors From manufacturers (1)
Cell Signaling polyclonal
IgG		 Rabbit
(liquid, HEPES, saline, BSA, glycerol, affinity purified)		 - Human, Monkey, Mouse, Rat, Drosophila Immunogen = a synthetic peptide (KLH-coupled) corresponding to human doublecortin detects endogenous levels of total doublecortin protein -
Notch, Jagged, Delta From manufacturers (1)
Cell Signaling monoclonal
IgG		 Rabbit
(liquid, HEPES, BSA, glycerol, saline, azide)		 - Human, Rat Immunogen = a synthetic peptide corresponding to the sequence at the Val1744 cleavage site of human Notch1 detects endogenous levels of the cytosolic domain of Notch1 only when cleaved between Gly1743 and Val1744; does not recognize full length Notch1 or Notch1 cleaved at other positions -
PSD95 From manufacturers (1)
Chemicon and Upstate are Millipore polyclonal
IgG		 Rabbit
(liquid, HEPES, saline, BSA, glycerol, affinity purified)		 - Rat immunogen = synthetic peptide from the N-terminal of rat PSD-95 reacts with rat PSD-95 and identifies a band at approximately 95 kDa -
Phosphatases From manufacturers (1)
Chemicon and Upstate are Millipore polyclonal
 Rabbit
(liquid, affinity purified Ig, phosphate buffer, saline, azide)		 - Rat immunogen = synthetic peptide from rat Spinophilin recognizes Spinophilin -
Synaptic Vesicle Fusion From manufacturers (6)
Calbiochem EMD Biosciences monoclonal
IgM		 Mouse
(purified serum, azide)		 - Pig, Human, Hamster, Rat immunogen = crude human synaptic immuno precipitate synaptophysin -
Chemicon and Upstate are Millipore polyclonal
 Rabbit
(liquid serum, azide)		 - Bovine immunogen = synthetic peptide from the C-terminal heptadeapeptide of mouse SNAP-25 (corresponding to residues Cys + 190-206: [C]RIDEANQR ATKMLGSG). reacts with SNAP-25; no cross reactivity with SNAP-23 is expected -
Chemicon and Upstate are Millipore polyclonal
 Rabbit
(liquid, affinity purified Ig, PBS, BSA, azide)		 - Human, Rat immunogen = synthetic peptide from human synaptophysin recognizes synaptophysin -
Chemicon and Upstate are Millipore polyclonal
 Rabbit
(affinity purified Ig, PBS, BSA, azide, lyophilized)		 - Rat immunogen = peptide corresp. to amino acids 1-19 from rat Synaptotagmin I recognizes Synaptotagmin I, luminal part; epitope does not share homology with any other known proteins -
Chemicon and Upstate are Millipore polyclonal
 Rabbit
(liquid, affinity purified Ig, HEPS, saline, BSA, glycerol)		 - Rat immunogen = synthetic peptide from rat/mouse/human Synaptotagmin, phospho Ser309 recognizes synaptotagmin, phospho Ser309. The immunogen sequence is identical in Synaptotagmin I, II and III.. -
Chemicon and Upstate are Millipore polyclonal
 Rabbit
(liquid, affinity purified Ig, HEPS, saline, BSA, glycerol)		 - Rat immunogen = synthetic peptide from rat/mouse/human Synaptotagmin, phospho Thr202 recognizes the 60-62 kD synaptotagmin, phospho Thr202. The immunogen sequence is identical in Synaptotagmin I, II and III.. -
Tools From manufacturers (1)
Pierce Thermo Scientific polyclonal
 Goat
(freeze-dried powder which can be reconstituted in water)		 - - immunogen = biotin can be used indetection and purification systems; can in turn be directly labelled or detected with a labelled anti-goat secondary antibody -
Tubulin From manufacturers (2)
Calbiochem EMD Biosciences monoclonal
IgG1		 Mouse
(liquid, PBS, gelatin, azide)		 - Chicken, Human, Gerbil, Mouse, Rat immunogen = native chick brain microtubules recognizes the ~60 kDa tubulin protein found in all eukaryotic cells -
Calbiochem EMD Biosciences monoclonal
IgG1		 Mouse
(liquid, PBS, gelatin, azide)		 - Chicken, Human, Gerbil, Mouse, Rat immunogen = native chick brain microtubules recognizes the ~60 kDa tubulin protein found in all eukaryotic cells -
γ-secretase/ Presenilins From labs (6)
B24.2(Bart De Strooper,K.U.Leuven, Belgium)PaperReference: Zhao, 2010 polyclonal
 Rabbit
(liquid, supernatant)		 - Mouse immunogen = the peptide KLDPSSQGAL QLPYDPEMEE (amino acids 306–325), coupled to KLH detects C-terminal fragments of PS-2 -
anti-PS1-NT1(Paul Mathews, New York University, School of Medicine,Center for Dementia Research)produced by CovanceReference: Gu, 2002 monoclonal
IgG1		 Mouse
(purified)		 - Primate (various), Human directed against residues 41-49 (RRSLGHPEP) of PS-1 recognizes full length PS-1 and the ~28 kDa amino-terminal fragment produced by in vivo proteolysis in L cells overexpressing PS1, but not proteins in mouse L cells overexpressing human PS2. NT1 recognized multiple bands migrating between 28 kDa and 35 kDa from human prefrontal cortex -
anti-PS1-C(Hui Zheng, Huffington Center on Aging, Baylor College of Medicine)used in paper by Xia, 2002 polyclonal
 Rabbit
 - - aa 454-467 of PS1 with glutamate residue added to N terminus to enhance solubility   -
B17(Bart De Strooper,K.U.Leuven, Belgium)Reference: Sato, 2007 polyclonal
 Rabbit
 - Human, Mouse immunogen = peptide p46 (EGDPEAQR RVSKNSKC), situated in the hydrophilic loop domain of PS1Paper PS1, hydrophilic loop-specific -
PS1-BI.3D7(Christian Haass,Adolf Butenandt Institute, University of Munich)used in paper by Steiner, 2002 monoclonal
- - fusion protein, C-terminal (aa 263-407) N terminus of PS-2 -
PS2 (GL2)(Takeshi Iwatsubo, Department of Neuropathology & Neuroscience, Grad. School of Pharmaceutical Sciences, University of Tokyo)References:Zhao, 2010Yu, 2001 polyclonal
 Rabbit
 - Human immunogen = GST fused to amino acids 301–361 of human PS2 detects C-terminus of PS-2 -
γ-secretase/ Presenilins From manufacturers (13)
Chemicon and Upstate are Millipore monoclonal
IgG1		 Mouse
(liquid, ascites, no preservative)		 - Primate (various), Mouse, Rat immunogen = Presenilin-1, loop fusion protein, C-terminal (amino acids 263-378), human Presenilin-1, loop. -
Abcam polyclonal
IgG		 Rabbit
(liquid, affinity purified, PBS, azide)		 - Human, Mouse, Rat immunogen = synthetic peptide (Human) of 13 amino acids from near the C-terminus of PEN2 detects Carboxy terminal end of PEN2 protein -
Zymed/ Invitrogen polyclonal
 Rabbit
(liquid, PBS, azide, affinity purified)		 - Human, Mouse immunogen = synthetic peptide derived from the C-terminal region of human Aph-1a Aph-1a (~23kDa) long isoform only -
A B R - Thermo Scientific polyclonal
IgG		 Rabbit
(epitope affinity purified IgG, PBS, BSA, azide)		 - Human, Mouse immunogen = synthetic peptide corr. to aa 688-708 of human nicastrin; one aa substitution between human and mouse sequence Nicastrin in tissues and cells; ~110 kDa in WB -
A B R - Thermo Scientific polyclonal
IgG		 Rabbit
(liquid, PBS, azide)		 - Human, Mouse, Rat immunogen = a 18 amino acid peptide sequence near the internal region of human nicastrin detects Nicastrin -
A B R - Thermo Scientific polyclonal
IgG		 Rabbit
(liquid, PBS, azide)		 - Human, Mouse, Rat immunogen = a 17 amino acid peptide sequence near the carboxy terminus of human nicastrin detects Nicastrin -
A B R - Thermo Scientific polyclonal
 Rabbit
(liquid, serum, azide)		 - Human immunogen = synthetic peptide corresp. to aa residues F Q I Y R P R W G A L G D Y L S F T I P L G T P of human Pen2 Pen-2 -
A B R - Thermo Scientific polyclonal
 Rabbit
(liquid, PBS, azide)		 - Human, Mouse, Rat immunogen = a 13 amino acid peptide sequence near the amino terminus of human PEN2. detects Pen-2, N-terminal -
A B R - Thermo Scientific polyclonal
IgG		 Rabbit
(IgG affinity purified, lyophilized)		 - Human, Hamster, Mouse immunogen = a synthetic peptide, conjugated to KLH, corresponding to the 11 most N-terminal residues of human Pen-2 detects Pen-2 -
A B R - Thermo Scientific polyclonal
 Rabbit
(liquid, affinity purified, PBS, BSA, azide, glycerol)		 - Human, Mouse immunogen = Synthetic peptide, KLH conjugated, corresponding to residues C(245)RRQEDSRVM VYSALRIPPED(265) of human APH-1aL/C-terminal recognizes APH-1 -
Sigma Aldrich polyclonal
 Rabbit
(buffered aqueous solution , IgG fract, PBS, azide)		 - Human immunogen = synthetic peptide corr to C-terminus, aa 693-709 of human nicastrin, conj. to KLH detects Nicastrin -
Santa Cruz monoclonal
IgG2b		 Mouse
(liquid, PBS, azide, protein stabilizer)		 - Human immunogen = amino acids 1-80 of Presenilin 1 of human origin for detection of Presenilin 1 NTF subunit of human origin; no cross with Presenilin 2 or Presenilin 1 CTF subunit -
BioLegend polyclonal
 Rabbit
(liquid, affinity purified)		 - Human immunogen = human Aph-1aL/ C-terminal region sequence C R R Q E D S R V M V Y S A L R I P P E D Aph-1aL Available from BioLegend