Clonality: polyclonal
Host: Rabbit
Source: PS2 (GL2)
(Takeshi Iwatsubo, Department of Neuropathology & Neuroscience, Grad. School of Pharmaceutical Sciences, University of Tokyo)
References:
Zhao, 2010
Yu, 2001
Reactivity:
Reacts in: Human
reference <a href="http://www.jbc.org/content/273/33/21153.full" target="_new">paper</a>: Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido T C, Maruyama K, Iwatsubo T. J. Biol. Chem 273, 21153-21160, 1998

Immunogen/Epitope

immunogen = GST fused to amino acids 301–361 of human PS2

Specificity

detects C-terminus of PS-2

Comments / Questions

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References

Paper Citations

1. Zhao G, Liu Z, Ilagan MX, Kopan R. Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. J Neurosci. 2010 Feb 3;30(5):1648-56. PubMed.
2. Yu H, Saura CA, Choi SY, Sun LD, Yang X, Handler M, Kawarabayashi T, Younkin L, Fedeles B, Wilson MA, Younkin S, Kandel ER, Kirkwood A, Shen J. APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron. 2001 Sep 13;31(5):713-26. PubMed.

External Citations

1. Takeshi Iwatsubo
2. paper

Further Reading

No Available Further Reading