The Antibodies database was archived in December 2022 and is no longer being updated. The Antibodies database is being supplanted by the AlzAntibodies database, which aims to provide detailed descriptions of selected antibodies.

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Antibodies

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	Name	Source	Clonality & Isotype	Host & Formulation	Method	Reactivity	Immunogen/ Epitope	Specificity	Availability
ADAMS & ADAMTS From manufacturers (1)
	ADAM17 /TACE (C-15)	Santa Cruz	polyclonal IgG	Goat (liquid, affinity purified, PBS, azide, gelatin)	-	Human, Mouse, Rat	immunogen = apeptide mapping at the C-terminus of TACE of human origin	for detection of precursor and mature TACE	-
APP, APLP, AICD From labs (1)
	APP (22C11)	(Konrad Beyreuther, Center of Molecular Biology, University of Heidelberg, Heidelberg, Germany)PaperReference: Kuhn, 2010	monoclonal	Mouse	-	Human, Monkey, Mouse, Rat	immunogen = a bacterial APP fusion protein (Fd-APP 695), (epitope in ectodomain, at residues 66-81 of APP)	detects a variety of mature as well as immature APP species which differ in their degree of glycosylation	-
Actin Related From manufacturers (1)
	Actin (I-19)	Santa Cruz	polyclonal IgG	Goat (liquid, PBS, azide, gelatin, affinity purifiedAlso available as:sc-1616-R (rabbit)sc-1616 FITC sc-1616 PEsc-1616 TRICT sc-1616 B (biotin)sc-1616 HRPsc-1616 AC Cat# sc1616 AF405, AF488, AF647; Alexa Fluor®)	-	Mammal (various), Dog, Zebra fish, Cow, Horse, Pig, Human, Mouse, Rat, Xenopus, C. elegans, S. cerevisiae, Drosophila	immunogen = peptide mapping at the C-terminus of human actin	broad range of Actin isoforms	-
Amyloid-β From labs (3)
	Aβ (BAN50)	BAN-50(N Suzuki,Takada Chemical Industries)References:Wang S, 2010Fukumoto, 2010Suzuki, 1994	monoclonal	Mouse	-	Human, Mouse	raised against Aβ 1-16 (epitope at aa 1-10)	amyloid-beta	-
	Aβ, N-terminal (1E8)	1E8(Paul Cutler,SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UKpaper: Cutler, et al, l997)	monoclonal	Mouse	-	Bovine, Human	immunogen = the derived peptide sequence aa. 13–22, (epitope at aa. 18-22, VFFAE) of beta amyloid	reacts with the N terminal of amyloid-beta; recognizes Aβ[1–40], Aβ[1–42] and Aβ[1–43]	-
	Aβ (3D6)	Elan Pharmaceuticals	monoclonal	Mouse	-	Human, Mouse	immunogen = synthetic peptide fragment conjugated to sheep anti-mouse immunoglobulin; epitope at aa 1-5 within Aβ42	Aβ (recognizes amino acids 1-5). Does not recognize secreted APP or APP-FL. Detects only Aβ species with amino-terminal aspartic acid.	-
Amyloid-β From manufacturers (3)
	Aβ 42 (G2-13)	Genetics Company, Inc.	monoclonal IgG1,κ	Mouse (liquid, stabilizing solution, no azide, affinity purified, conj. HRP)	-	Dog, Human, Guinea Pig, Mouse, Rat, Cynomolgus	immunogen = Aβ 1-42 peptide at the C-terminus	C-terminal of Aβ 1-42 peptide; not Aβ 1-38, Aβ 1-39, Aβ 1-40; low cross reactivity to Aβ 43 (10%)and Aβ 44 (13%)	-
	β-Amyloid	Cell Signaling	polyclonal	Rabbit (liquid, HEPES, NaCl, BSA, glycerol, affinity purified)	-	Bovine, Human, Rat	immunogen = synthetic peptide corresp. to residues at the N-terminus of human β-Amyloid peptides	detects several isoforms of β-amyloid peptide (Abeta), such as Abeta-40, Abeta-42 etc, regardless of phosphorylation state	-
	Amyloid β [1-42] and Aβ [1-40]	Innogenetics	kit	Unknown Host (well standardized multiparameter bead-based immunoassay for the simultaneous quantification of human ß-amyloid in plasma using xMAP® (registered trademark of Luminex Corp)technology)	-	Human	Uses 3D6 antibody;3D6 selectively binds Aß peptides with a free aminogroup at Asp1 (epitope 1–5)	for simultaneous quantification of different forms of β-amyloid in blood, with check for matrix interference	-
Apolipoproteins From manufacturers (1)
	Apo E (M-20)	Santa Cruz	polyclonal IgG	Goat (liquid, affinity purified, PBS, azide, blocking peptide)	-	Mouse, Rat	immunogen = a peptide mapping at the carboxy terminus of mouse ApoE	Apo E	-
Glutamate Receptor & Related From manufacturers (1)
	NR2A	Chemicon and Upstate are Millipore	polyclonal	Rabbit (liquid, unpurified serum, azide)	-	Mouse, Rat	immunogen = GST-tagged recombinant protein corresponding to rat NR2A at the C-terminus	recognizes NR2A (~176 kDa) at the C-terminus	-
Histones & HDACs From manufacturers (1)
	HDAC6 (H-300)	Santa Cruz	polyclonal IgG	Rabbit (liquid, PBS, azide, gelatin)	-	Human	immunogen = epitope corresp. to aa 916-1215 mapping at the C-terminus of HDAC6 of human origin	detects HDAC6, 160 kDa	-
MAPKs From manufacturers (1)
	ERK 2 (C-14)	Santa Cruz	polyclonal IgG	Rabbit (liquid, PBS, gelatin, azide, afffinity purified)	-	Chicken, Zebra fish, Human, Mouse, Rat, Xenopus	Immunogen = peptide mapping at the C-terminus of rat ERK 2	detects ERK 2 p42, and to a lesser extent, ERK 1 p44	-
MAPs From manufacturers (1)
	MAP1 light chain LC3 (2G6)	nanoTools Antikörpertechnik GmbH & Co.	monoclonal IgG1	Mouse (liquid)	-	Human, Monkey, Hamster, Mouse, Rat	immunogen = synthetic peptide conjugated to hemocyanin (epitope at N-Terminus of LC3-B)	recognizes MAP1 light chain component LC-3	-
Mitochondrial Proteins, Microglial Markers From manufacturers (1)
	Anti-PBR antibody (EPR5384)	Abcam Cat# ab109497	monoclonal IgG	Rabbit (Tissue culture supernatant. PBS 49 percent, sodium azide 0.01 percent, glycerol 50 percent, BSA 0.05 percent.)	-	Human, Mouse	A synthetic peptide corresponding to residues at the C-terminus of human peripheral benzodiazepine receptor (PBR)/translocator protein (TSPO).	This antibody recognizes PBR, also known as TSPO, a mitochondrial transporter that is upregulated in activated microglia.	Confirmed available December 2014.
Motor Proteins From manufacturers (1)
	KHC (H2)	Chemicon and Upstate are Millipore	monoclonal IgG2b	Mouse (liquid, phosphate buffer, saline, azide)	-	Mammal (various), Chicken, Sea Urchin, Squid, Human, Mouse, Rat, Clam	immunogen = bovine brain kinesin, epitope at aa 420-445	Reacts with the heavy chain of kinesin near the N-terminus	-
Nitric Oxide From manufacturers (1)
	iNOS (54)	BD Transduction	monoclonal IgG1	Mouse (aqueous buffered solution containing BSA, glycerol, azide)	-	Mouse	immunogen = mouse iNOS aa. 961-1144 at C-terminal	recognizes ~130 kDa iNOS; reported to cross-react with nNOS and eNOS	-
Phosphatases From manufacturers (1)
	STEP (23E5)	Santa Cruz	monoclonal IgG1	Mouse (liquid, PBS, gelatin, azide)	-	Mouse, Rat	immunogen = an 18 amino acid sequence mapping at the N-terminus of STEP46 of rat origin	for detection of all known isoforms of STEP of mouse and rat origin	-
Posttranslational Modifications From labs (1)
	Ubiquitin+1, frameshift mutant	Ubi-B1 and Ubi-B2(Fred W. van Leeuwen, Netherlands Institute forBrain Research, Amsterdam, Netherlands)Paper	polyclonal	Rabbit (See also R&D systems antibodies MAB703 andAF703)	-	Human	immunogen = synthetic peptides covering YADLRED PDRQDHH PGSGAQ at the C-terminus of Ubiquitin+1	reacts with Ubiquitin+1 and not Ubiquitin	-
Secreted Neuropeptides & Receptors From manufacturers (2)
	Orexin-A	Santa Cruz	polyclonal IgG	Goat (liquid, affinity purified IgG, PBS, azide, gelatin)	-	Dog, Pig, Human, Mouse, Rat	immunogen = a peptide mapping at the C-terminus of Orexin-A of human origin	for detection of Orexin-A processed active peptide	-
	Urocortin (R-20)	Santa Cruz	polyclonal IgG	Goat (affinity purified, PBS, azide, gelatin)	-	Cow, Human, Mouse, Rat	immnuogen = a peptide mapping at the C-terminus of urocortin of rat origin	detects urocortin	-
Synucleins From labs (1)
	α-Synuclein	α-Synuclein LB509(Takeshi Iwatsubo, Department of Neuropathology & Neuroscience, Grad. School of Pharmaceutical Sciences, University of Tokyo)Also see Abcam ab27766, SantaCruz sc-58480, and others.References:Tokuda, 2010Tsika, 2010Xu, 2002	monoclonal	Mouse	-	Human	(epitope at the C terminus of the protein, residues 115-122)	detects α-Synuclein, C-terminal	-
TAR DNA-binding protein /TDP-43 From manufacturers (1)
	Anti-phospho TDP-43 (ser409/410) (1D3)	Millipore Cat# MABN14	monoclonal IgG2ak	Rat (Purified in buffer containing 0.1 M Tris glycine with 0.05% sodium azide)	-	Human	Ovalbumin-conjugated linear peptide corresponding to human TDP-43 phosphorylated at serine 409 and 410.	This antibody recognizes human TDP-43 phosphorylated at serine 409 and 410.	Confirmed Oct 2014
Tau From labs (4)
	acetylated Tau /ac-tau	Ab708Li Gan, Gladstone Institute of Neurological DiseaseAssistant Professor of NeurologyUniversity of California, San FranciscoReference: Min SW, 2010	polyclonal IgG2b	Rabbit	-	Human, Rat	immunogen = a synthetic tau peptide (amino acids 160–182 for 2N4R tau isoform) containing acetylated lysines at positions 163 and 174 and 180	Ab708 specifically recognizes tau acetylated by p300 under cell-free conditions. In HEK293T cells transfected with tau, overexpression of p300 markedly elevatedthe levels of ac-tau detected with Ab708 while the increase in the levels of t-tau was modest, suggesting that Ab708 preferentially recognizes p300-induced ac-tau in cultured cells. Ab708 recognizes human tau acetylated at positions 163, 174, or 180 and possibly other acetylated lysines on tau, but not nonacetylated tau	-
	Tau (12E8)	Philip Dolan, Prothena Biosciences, South San Francisco, CA	monoclonal	Mouse	-	Mammal (various), Human, Zebra fish, Drosophila, C. elegans	immunogen = tau phosphorylated at S262 in KXGS motif of the 4th repeat and/or Ser356	tau phosphorylated at S262 and/or S356	-
	Tau (DA9)	Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org.	monoclonal IgG1	Mouse	-	Human, Mouse	epitope at aa102–140	recognizes total tau	-
	Tau (TG-3)	Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org.	monoclonal IgM	Mouse (IC, IF, IH, IP, WB)	-	Human	Tau phosphorylated at threonine-231; also conformation-sensitive.	Tau phosphorylated at threonine-231; also conformation-sensitive. Not reactive to normal tau. The TG3 epitope is expressed in mitotic cells but not in quiescent cells, suggesting that mitotic phosphoepitopes may lead to conformational changes.	-
Tau From manufacturers (9)
	Tau, truncated, cleavage site 421/422 (Tau-C3)	Biosource Invitrogen	monoclonal IgG1,κ	Mouse (affinity purified ascites, PBS, BSA, azide, unconj.)	-	Human, Mouse, Rat	immunogen = KLH- CSSTGSIDMVD, corresp. to the C-terminus of tau truncated at Asp421	recognizes tau when truncated at Asp421; no reaction with full-length tau, or with tau truncated at Glu391 or Ala429	-
	Tau pT181	Biosource Invitrogen	kit	Unknown Host (contains:Hu Tau [pT181]Antibody Bead Concentrate;Hu Tau [pT181]Detection Ab Concentrate;Hu Tau [pT181] Standard)	-	Human	human tau-derived peptide that is phosphorylated at threonine 181	for the measurement of human Tau when phosphorylated at threonine 181 in CSF and tissueculture media	-
	Tau-1 (PC1C6)	Chemicon and Upstate are Millipore	monoclonal IgG2a	Mouse (purified Ig, phosphate buffered, lyophilized)	-	Bovine, Human, Rat	immunogen = purified denaturated bovine MAPs (epitope at or near a phosphorylated site)	binds to all known electrophoretic species of tau in human, rat and bovine brain (one-dimensional SDS-PAGE); there is some unphosphorylated bias with clone PC1C6 as it seem to recognize only dephosphorylated serine sites at 195, 198, 199, and 202	-
	Tau pT205	Biosource Invitrogen	polyclonal	Rabbit (purified Ig, PBS, BSA, azide, glycerol, unconjugated)	-	Human	human tau-derived peptide that is phosphorylated at threonine 205	tau phosphorylated at threonine 205	-
	Tau pS422	Biosource Invitrogen	polyclonal	Rabbit (purified Ig, PBS, BSA, azide, glycerol, unconjugated)	-	Human	human tau-derived peptide that is phosphorylated at serine 422	tau phosphorylated at serine 422	-
	Tau (AT270)	Pierce Thermo Scientific	monoclonal IgG1κ	Mouse (supernatant, affinity purified, no carrier or preservativeAlso available biotin conj., MN-1050B)	-	Human	immunogen == partially purified human PHF tau, aa. around phosphorylated Thr181	PHF tau, tamgles and neurofilaments; no cross with recomb. unphospho tau; weak cross with normal tau	-
	Tau (AT180)	Pierce Thermo Scientific	monoclonal IgG1κ	Mouse (purified, no carrier or preservative)	-	Human	immunogen = aa. around phosphorylated Thr231	detects Tau doubly phosphorylated at Thr231 and Ser235; weak recognition of phosphorylation at Thr231 only	-
	Tau phos Thr181 (AT270)	Innogenetics	monoclonal IgG1κ	Mouse (liquid, sterile filtered, PBS, no preservative, affinity purified)	-	Human	immunogen = human tau40, aa. around phospho. Thr 181	specific for tau phospho at Thr 181; as PHF-tau, tangles and neurofilaments; weak cross with normal tau;	-
	Tau (AT8)	Pierce Thermo Scientific Cat#  MN-1020	monoclonal IgG1κ	Mouse (Protein A affinity purified, PBS, no preservative)	-	Baboon, Human, Rabbit, Hamster, Avian (various), Drosophila	immunogen = partially purified human paired helical filament tau.	Recognizes tau protein phosphorylated at both serine 202 (Ser202) and threonine 205 (Thr205). Does not cross-react with unphosphorylated forms of tau.	Confirmed available April 2015.
Tubulin From manufacturers (1)
	α-Tubulin (DM1A)	Sigma Aldrich	monoclonal IgG1	Mouse (liquid, purified IgG, PBS, BSA, azideAlso available as ascites and as FITC conj.)	-	Bovine, Chicken, Human, Mouse	immunogen = purified chick brain tubulin (epitope at aa 426-430)	recognizes an epitope located at the C-terminal end of alpha-tubulin	-
p38 MAPK & MAPK11-14 From manufacturers (2)
	p38 MAPK phos Thr180/Tyr182 (3D7)	Cell Signaling	monoclonal IgG	Rabbit (liquid, HEPES, NaCl, BSA, glycerol)	-	Mink, Human, Monkey, Mouse, Rat	Immunogen = synthetic phospho-peptide corresp. to residues surrounding Thr180/Tyr182 of human p38 MAP kinase conj. to KLH	Detects endogenous levels of p38 MAP kinase only when dually phosphorylated at Thr180 and Tyr182. Does not cross-react with the phosphorylated forms of either p42/44 MAPK or SAPK/JNK	-
	p38 MAPK phos Thr180/Tyr182	Cell Signaling	polyclonal	Rabbit (liquid, HEPES, NaCl, BSA, glycerol, Protein A and peptide affinity purified)	-	Pig, Human, Monkey, Mouse, Rat, S. cerevisiae, Drosophila	Immunogen = synthetic phospho-peptide corresp. to residues around Thr180/Tyr182 of human p38 MAP kinase	Detects endogenous levels of p38 MAP kinase only dually phosphorylated at Thr180 and Tyr 182. Does not cross react with phosphorylated forms of p42/44 MAPK or SAPK/JNK	-