Lowering Tau Tips the Brain's Balance of Excitation/Inhibition
In tau knockout mice, excitatory neurons fire less; inhibitory neurons fire more. Could this dampen hyperexcitability in conditions such as Alzheimer’s?
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Losing NEMO: Could This Protein Explain COVID Brain Fog?
A SARS-CoV-2 protease cleaves the transcription factor NEMO, which protects the brain's endothelial cells. In people who had COVID, and mice lacking NEMO, blood vessels shriveled. Could long COVID increase risk for dementia?
In Preclinical Alzheimer's, p-tau217 in Blood Best Predicts Tangles
Tau PET holds a slight edge over the plasma marker in people who already have mild cognitive impairment.
Mighty MiGA: Microglial Genomic Atlas Zeros in on Causal AD Risk Variants
The largest transcriptomic catalogue of live microglial cells to date, MiGA cinched causal connections between genetic variation, microglial gene expression, and disease.
In Frontotemporal Dementia Model, Do Riled-Up Microglia Help?
Progranulin deficiency hyperactivates microglia, but calming these cells worsened synapse loss and neurodegeneration in mice.
Stroke Severity, Recurrence Increase Dementia Risk
Dementia risk nearly doubled after each minor stroke and tripled after each major one, regardless of vascular risk factors. Risk climbed almost sevenfold after multiple major strokes.
Benzodiazepines Coax Microglia to Prune Synapses, Impair Cognition
The data, from mice, help explain how these depressants may increase a person’s risk for dementia.
Not Just Aβ—Glymphatic Flow Clears Tau, Too, Slowing Its Aggregation
Retarding glymphatic clearance in mice caused p-tau to accumulate faster, and hastened neurodegeneration.
Sniff This: Therapeutic Peptides Through the Nose?
Peptides make lousy drugs, especially for the brain. When taken as a pill or by infusion, they either bounce off the blood-brain barrier, or get degraded within minutes...
How Does COVID-19 Affect the Brain?
Some people with severe COVID-19 have neurovascular injury and elevated markers of neural damage in their blood and CSF. What’s going on in their brains?
In First for the Field, α-Synuclein PET. Only for Multiple System Atrophy
A new tracer detects α-synuclein aggregates in people with multiple system atrophy. Binding is weak, and undetectable in people with other synucleinopathies.
Like Star Born of Supernova, Plaque Born of Exploded Neuron?
if Charlie Glabe is right, an exploding neuron does expel material that then triggers the formation of new, stable matter in its surroundings...
Robust TREM2 Expression May Delay Alzheimer’s Disease
In familial AD, the faster sTREM2 rises in a person's cerebrospinal fluid, the slower his or her amyloid grows, cortex thins, and cognition fades.
From Near and Far, Aβ Beckons Tau to Tangle in the Cortex
Interactions with both remote and local amyloid-laden neurons drive tangles through the Alzheimer's brain. Is person-to-person variability in these interactions why patients differ in their progression?
Tau-PET Imaging Brings Braak Staging to Life
Using a sensitive tau-PET tracer, researchers tied neuroimaging, CSF biomarkers, and cognitive symptoms to the progression of tau pathology in AD.
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