Semagacestat Failure Analysis: Should γ-Secretase Remain a Target?
A debate has sprung up in response to a Cell essay arguing that the baby was thrown out with the bathwater when a γ-secretase inhibitor failed in Phase 3.
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Consortium Debuts Biggest Set of Human Epigenomes To Date
Large consortium releases epigenome profiles of 111 different tissues. They are already yielding insight into the immune system’s role in Alzheimer’s disease.
Tau Gene Confirmed to Amp Up Alzheimer’s Risk and Neurodegeneration
A risk allele previously linked to Parkinson’s is now extended to Alzheimer’s as well, with particularly strong effects in patients who lack an ApoE4 allele.
Propagation Blues? Reporter Expression Clouds Reports of Traveling Tau, Aβ
A mouse model that was previously thought to express a transgene predominantly in the entorhinal cortex may be much leakier than previously thought. This complicates interpretation of some previous studies reporting propagation of toxic tau aggregates.
First C9ORF72 Mice Mimic Key Pathology, Behavior
Using a viral vector, researchers created mice that express C9ORF72 hexanucleotide repeats in the brain.
Could New Fluid Biomarkers Refine Alzheimer’s Diagnosis?
In separate studies, researchers propose that high CSF ferritin and D-serine could become biomarkers to predict declining cognition in Alzheimer’s disease.
Shape of a Hug: How the Embrace of a Therapeutic Aβ Antibody Really Matters
A new crystal structure shows a unique shape of Aβ in the arms of solanezumab. Exactly how this and other antibodies in the clinical pipeline grip Aβ could explain some differences in trial results.
Dueling Data Variously Say Diabetes Increases, or Decreases, ALS Risk
However, once a person has ALS, diabetes does not affect how long they survive.
Blood Marker May Predict ALS Progression
Levels of a neuronal protein in blood correlated with rate of decline in two U.K. cohorts.
To Be Hale and Hearty, Brain Microglia Need a Healthy Gut
Proper form and function of the brain’s immune cells depend on a diverse mix of “good” bacteria in the mouse intestine.
Mutations Open Cavity in Profilin, Destabilize the ALS-Linked Protein
Could filling these cavities with a small molecule be therapeutic?
Exosomes Divulge Lysosomal Unrest, Signal AD?
Neuron-derived vesicles floating in the blood carry protein signatures that flag lysosomal dysfunction. Could they detect preclinical Alzheimer’s disease?
ALS Model Worms Sicken Via Innate Immune Pathway
The model provides the first functional evidence of how the ALS gene UNC13A modifies disease risk.
‘Frontal AD’ a Misnomer? Behavioral Variant Has Minimal Frontal Atrophy
A behavioral variant of Alzheimer’s disease is not accompanied by shrinking of the frontal cortex. Rather, these patients have similar patterns of atrophy as those with typical AD.
Enhanced Autophagy Protects Against ALS Proteotoxicity
Blocking a family of proteins called cytohesins helped clear toxic SOD1. Scientists speculate the inhibition just might do the same for other proteins linked to neurodegeneration.
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