Amyloid-PET Results Lead Some to Ponder Assisted Death in Future
In a research study, one-fifth of healthy people who learned they were at high risk for AD said they might consider physician-assisted death as a future option.
ALL NEWS
6566 RESULTS
Sort By:
- Most Recent
- Most Commented
Off-Balance Endocytosis Lays Groundwork for Disease
By aging cultured neurons and manipulating them to stimulate endocytosis or interfere with vesicle release, researchers can bring about characteristics of Alzheimer’s—without adding APP or Aβ.
Plasma NfL Goes the Distance in Alzheimer’s
In ADNI, blood marker exposes ongoing neurodegeneration across disease stages.
Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80
Scientists propose that LATE is a neurodegenerative disease marked by TDP-43 pathology in limbic regions, and memory loss. After death, it can be seen alone or with other pathology.
On The Docket at AD/PD: The Many Crimes of ApoE4
Microglia cleanup, mitophagy, axonal plasticity, blood-brain barrier. A renewed focus on ApoE4 is revealing new ways in which this isoform renders the brain vulnerable to Alzheimer’s.
ARIAS: Zooming in On Eye-based Biomarkers for Alzheimer’s
Scientists know that the retina changes in people with preclinical AD; alas, there is neither consensus nor convergence in the field of retinal imaging. An upcoming initiative aims to determine which measures are most robust.
Spitting, Sniffing: Is This How We Will Dx Parkinson’s?
Scientists are probing saliva and skin secretions for telltale signs of Parkinson’s disease. Their prize? A diagnostic test at the pre-motor stage.
Chimeric Mice: Can They Model Human Microglial Responses?
By slipping human microglia inside the mouse brain, researchers hope to better monitor their response to pathologies, such as Aβ.
Light Is Alright: Mild Physical Activity Comes With Larger Brain
People who take leisurely walks, garden, and tackle household chores had bigger brains than those who were more sedentary. Vigorous exercise brought neither additional benefit nor harm.
New Money to Spur Tech Search for AD Biomarkers
Diagnostics Accelerator to fund projects that develop dementia biomarkers from patient data.
Older Children with Spinal Muscular Atrophy Improve on Nusinersen
Long-term treatment with the anti-sense oligonucleotide led to motor benefits in an extension trial of children 2 to 15 years old.
Could Greasing the Wheels of Lipid Processing Treat Alzheimer’s?
Speakers at AD/PD 2019 reported that AD risk factors mess up lipid metabolism in glial cells. In cellular models, speeding the clearance of fats lessened pathology.
Could CD33 Be the Microglial Target for Stimulating Phagocytosis?
Inhibiting the receptor activates microglia to mop up debris, making CD33 an attractive therapeutic target.
Parsing How Alzheimer’s Genetic Risk Works Through Microglia
Scientists at AD/PD 2019 see a Goldilocks of microglial activation: Both too little and too much is bad in an injured brain. How could a therapy make it just right?
Life Without Microglia: Rare Cases of CSF-1R Mutations Paint a Grim Picture
In people carrying two mutated copies of the trophic receptor, important brain structures, such as the corpus callosum, never developed.
Current Filters
No filters selected