New Assay, New Cohorts—Plasma p-Tau181 Looks Even Better
At AAT-ADPD, researchers report how they built on prior reports that a person’s blood level of p-tau181 tells if they have Alzheimer’s.
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Low-Dose Aspirin Does Not Prevent AD, or Slow Cognitive Decline
A trial of nearly 20,000 participants found no benefit over five years.
A Phospho-Tau Plasma Assay for Alzheimer’s?
Two papers report that phosphorylated tau in the blood distinguishes people with AD from healthy controls and from people with frontotemporal and vascular dementias.
A ‘Perfect Storm’ for Families Grappling with Dementia
From caregivers going it alone to understaffed nursing homes on lockdown, people with neurodegenerative disease and their caregivers are feeling enormous strain from the novel coronavirus. They are adapting to the new normal with technology.
Coronavirus Takes Its Toll on Alzheimer’s Clinical Studies
Most observational cohorts are on pause, and many clinical trials have stopped dosing. The long-term effects on the integrity of AD studies are unclear.
Social Distancing Shutters Alzheimer’s Research
With experiments and careers on hold, scientists working from home are turning to virtual lab meetings and journal clubs to keep up morale.
Dementia Research Institute to Double U.K. Coronavirus Testing
United Kingdom’s DRI pivots to fight COVID-19. The facility could test 10,000 samples per day.
Stress-Associated Protein Modulates γ-Secretase to Make More Aβ
Under diabetic conditions, SERP1 binds secretase subunit, cranking up cleavage of APP but not Notch. The finding offers a mechanistic link between diabetes and Alzheimer’s.
Traveling C9ORF72 Dipepides Jam Proteasomes in Neighboring Neurons
The slowdown of proteasomes stymied TDP-43’s entry into the nucleus and promoted its aggregation in the cytoplasm.
Alzheimer’s Gene BIN1 Promotes Synaptic Transmission
In a conditional mouse knockout, lack of neuronal BIN1 slowed excitatory signaling, leading to spatial memory problems. Could this play a role in Alzheimer’s?
Plaques, Tangles Throw Off the Brain’s Rhythms
In the human brain, alpha waves fell out of sync, while delta-theta waves swelled in concert with amyloid plaques, neurofibrillary tangles. Alpha modulation correlated with cognitive decline.
Different CSF Phospho-Taus Match Distinct Changes in Brain Pathology
Different forms of p-tau in cerebrospinal fluid reflect worsening plaque load, metabolism, and atrophy in the brain. They could help stage Alzheimer’s disease.
Primary Care Physicians Unprepared to Handle Future Alzheimer’s Case Loads
A survey conducted by the Alzheimer’s Association finds that three-quarters of these physicians had little to no residency training in dementia care.
Without TMEM106B, Lysosomal Traffic Jams Wreak Havoc in Neurons
In motor neurons of TMEM106b knockout mice, swollen vacuoles piled up in axons near the soma, rendering the mice wobbly and slow to react. The finding contradicts prior reports.
Paper Alert: Mouse TREM2 Antibody Boosts Microglial Plaque Clean-Up
The monoclonal antibody activated TREM2 signaling on mouse microglia. It supported their survival and stimulated their clearance of amyloid plaques.
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