Tau Receptor Identified on Cell Surface
At Tau2020 conference, scientists implicate LDL receptor-related protein 1 in cell-to-cell transmission.
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Primary Tauopathies Get New PET Ligands
Autopsy data confirm that current tau PET tracers are unsuitable for some primary tauopathies. CryoEM structures help researchers find new ligands for tau and α-synuclein.
New at Tau2020: PET Detects First Traces of Tangles in Rhinal Cortex
Not sure where that is? You are not alone. It is a tiny spot deep behind the nose, newly defined by the PET signal of early neurofibrillary tangle deposition. It also prompted a tau-staging scheme.
Behold the First Human α-Synuclein CryoEM Fibril Structure
At the at Tau2020 conference, scientists show high-resolution cryoEM of α-synuclein. Two different types of fibril are composed of asymmetric protofibril units.
Resilience Redefined: Sharp at Age 100, Still Sharp at 102
Centenarians who scored high on the MMSE stayed cognitively and physically active over the next two years, even if they carried genetic risk factors for Alzheimer’s. What protects these lucky few?
Tau2020: Meeting for Tauopathies Debuts Genetic Variants
By engaging scientists studying every tau-based disorder, a new conference aimed to foster collaborations and research directions.
Tau2020 Global Conference
Tau2020: Meeting for Tauopathies Debuts Genetic Variants Behold the First Human α-Synuclein CryoEM Fibril Structure New at Tau2020: PET Detects First Traces of Tangles in Rhinal Cortex Primary Tauopathies Get New PET Ligands Tau Receptor Identified on Cel
How Much Amyloid Will Kick Off Tangles, and Decline?
At HAI 2020, scientists more precisely quantified the relationship between plaques, tangles, and cognitive decline.
In Aging, Epigenetic Wet Blanket Douses Mitochondria
Two epigenetic proteins accelerated age-related behavioral decline in worms and in mice, at least partly by dampening mitochondrial function. Orthologs in the human brain ramped up with aging and with AD progression.
Can PET Match Up Areas of Protein Deposit With Alzheimer’s Symptoms?
Amyloid and tau PET are helping scientists pinpoint the underlying cause of specific AD symptoms. Perhaps imaging of certain brain regions will help predict an individual’s progression.
Tau PET: The Field Expands Rapidly
At the HAI 2020 conference, the tracers PI-2620 and APN-1607 appeared to bind frontotemporal dementia tau. MK-6240 looked highly sensitive. And JNJ-067 and SNFT-1 are two new kids in town.
Retinal Gene Therapy Trial Posts Positive Result
Vision improved in some retinitis pigmentosa patients in a Phase 1 trial.
Ruffles and Sphincters Control the Spigot of Fresh Blood in the Brain
Two studies reveal new aspects of the neurovascular physiology that regulate the flow of oxygenated blood into the brain’s arterioles and capillaries in response to neuronal stimulation.
Can BACE2 Protect Against Amyloidosis?
The protease suppresses Aβ in Down’s syndrome organoids.
CryoEM of CBD Tau Suggests Another Unique Protofibril
Post-translational modifications differ from those in AD tau fibrils, and may dictate tau strains.
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