EMIF, GAAIN: Online Gateways to Reams of Alzheimer’s Data
Two international initiatives compile metadata from aging and AD studies into huge searchable catalogs in hopes of speeding research progress.
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Positive Trials of Spinal Muscular Atrophy Bode Well for Antisense Approach
Trial sponsors moved children from ongoing trials to open-label studies following positive interim results of an antisense oligonucleotide treatment.
New Spectroscopy Method Detects Myelin Changes in Early ALS
Before any other changes, the fatty coating on peripheral nerve fibers breaks apart, heralding their degeneration.
New Tracer May Prove Better for Amyloid PET
Fluselenamyl avoids white matter and binds diffuse plaques
Live Monitoring Study Shows Only Blood Insulin Triggers Rise in Brain Aβ
Insulin delivered directly to the brain does nothing to Aβ in an AD mouse model, complicating the relationship between diabetes and Alzheimer’s.
Do Microbes in the Gut Trigger Parkinson’s Disease?
In a PD mouse model, microbes pump out short-chain fatty acids that worsen synuclein aggregation and motor problems. Intestinal flora from people appears to do the same.
Astrocytes and Exosomes Implicated in Protein Propagation
Researchers at SfN 2016 painted a more detailed picture of how misfolded proteins may proliferate, as one cell spreads these “hot potatoes” to the next.
New Reporter Cells Parse Differences Between Tau Strains
Cell lines can serve as sensors for strains found in different human tauopathies.
Society for Neuroscience
Astrocytes and Exosomes Implicated in Protein Propagation Knock-In Alzheimer’s Mice Catch on More Broadly in the Field Next-Generation Mouse Models: Tau Knock-ins and Human Chimeras Inflammation Helps Microglia Clear Amyloid from AD Brains Exosomes and An
Knock-In Alzheimer’s Mice Catch on More Broadly in the Field
Researchers at SfN 2016 touted the advantages of APP knock-ins, but noted they are less useful than overexpression models for studying behavior.
Paper Alert: Slotting TREM2 into Alzheimer’s Pathogenesis
Where does TREM2-dependent microglial activity fit into the staging diagram of Alzheimer’s disease?
Exosomes and Antibodies Tie Plasma Aβ and Tau to Alzheimer’s
Researchers at SfN 2016 reported that oligomeric and exosomal forms in plasma predict AD as early as a decade prior to symptoms.
Clinical Trials on Alzheimer's Disease
CTAD: Solanezumab Seen to Nudge AD Ever so Slightly Tau Inhibitor Fails Again—Subgroup Analysis Irks Clinicians at CTAD Much ‘Adu’ About a Little: Phase 1 Data Feeds the Buzz at CTAD Tau PET in Down’s: Unique Patterns Among Alzheimer’s Types and Stages Em
Tau Inhibitor Fails Again—Subgroup Analysis Irks Clinicians at CTAD
The tau aggregation inhibitor LMTM tanks in second Phase 3 trial for Alzheimer’s. The sponsor now plans to develop the “placebo.”
From Stem Cell Exosomes to Restoring ZZZs: New Ideas to Protect the Brain
Scientists at SfN presented innovative ways to slow amyloid accumulation and preserve synapses.
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