Blueberries for All?
Just grind some dehydrated blueberries into your people-chow and counteract the effects of aging and Alzheimer's disease on memory. That's one hypothesis we can take away from a recent study by Jim Joseph and colleagues...
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LTP and Memory Effects May Be the First Casualties in AD
In Alzheimer's disease (AD), the first significant damage to neurons may be the loss of proteins involved in long-term potentiation (LTP) and memory. So conclude Dave Morgan and colleagues from the University of South Florida, Tampa, and Incyte Genomics, Palo Alto, California, in the June 15 Journal of Neuroscience...
Organization for Human Brain Mapping 2003 Annual Meeting
Seeing Alzheimer’s: Advances in Brain Mapping Bring Goal a Step Closer Organization for Human Brain Mapping 2003 Annual Meeting
Seeing Alzheimer’s: Advances in Brain Mapping Bring Goal a Step Closer
I-han Chou reports from Brain Mapping Conference in New York City.
Neurexins: Building Gaps, Then Bridging Them
Synapses—those specialized junctions that facilitate transmission of action potentials between neurons—are composed of a myriad of highly sophisticated proteins. Some, like neurexins, have yet to be fully characterized...
Serotonin-induced Release of sAPPα Is Mediated by Rap and Rac
In this month's Nature Cell Biology, Frank Lezoualc'h and colleagues at the University of South Paris report that serotonin, or 5-hydroxy tryptamine (5HT), mediates sAPPα release through a cyclic AMP (cAMP) signaling pathway independent of protein kinase A (PKA)...
Gabrielle Strobel Interviews Vincent Marchesi
Alzforum scientific advisor Vincent Marchesi is currently director of the Boyer Center of Molecular Medicine at Yale University School of Medicine.
Ancient Defense Mechanism Causes Collateral Damage to Neurons
In the 24 June PNAS Early Edition, researchers report that a biologically ancient defense mechanism for ridding the central nervous system (CNS) of invading pathogens also damages neurons...
U.S. Study Questions the Value of CJD Test
Soon after the World Health Organization bestowed its approval on the protein 14-3-3 as an important diagnostic marker for sporadic Creutzfeldt-Jakob disease (sCJD), reports began to come in that its sensitivity and specificity might not be all that was advertised...
Nicotine and β Amyloid—Smoking Guns?
Papers in press in the Journal of Biological Chemistry and PNAS explore the relationship between Alzheimer's disease (AD) and nicotine...
FDA Approves L-dopa Cocktail for Parkinson’s
The U.S. Food and Drug Administration has given approval for the drug Stalevo—a cocktail of levodopa (L-dopa), carbidopa, and entacapone—to be marketed in the United States for the treatment of Parkinson's disease...
Plugging Up the Blood-Brain Barrier
The blood-brain barrier (BBB) is cropping up with increasing frequency in discussions of Alzheimer's disease therapy. It is an ever-present concern for researchers hoping to introduce therapies...
Nonprofit Foundation Strikes Deal with Stem Cell Pioneer
The not-for-profit Amyotrophic Lateral Sclerosis-Therapy Development Foundation (ALS-TDF), based in Newton, Massachusetts, has entered into a collaboration with University of Chicago stem cell researcher Kimonobu Sugaya...
Spotlight on the DJ: Crystal Structure Solved of Parkinson's Protein
Two in-press papers in the Journal of Biological Chemistry reveal the crystal structure of DJ-1, a protein of unknown function that was recently implicated in the etiology of familial Parkinson's disease...
Small Molecules Turn Stem Cells into Neurons, Targeting GSK3β
In last week's PNAS online, researchers reported that murine embryonic stem cells exposed to pyrrolpyrimidines differentiate into neurons. This result raises hope that the fate of stem cells in vivo may one day be controlled by the use of small molecules...
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