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The prolyl isomerase Pin1 protects against tau-mediated, age-dependent neurodegeneration, according to a study in the July 31 Nature. Kun Ping Lu, at Harvard Medical School, and his colleagues combine human postmortem data in AD brains with a Pin1 knockout mouse...
Despite evidence that NSAIDS do little to help those already suffering from Alzheimer's disease, a report in the British Medical Journal supports the contention that they may stave off Alzheimer’s, or at least slow its progression...
Bored with the same old foods you tend to eat? Consider adding more fish and some specific plant products. Two recent studies suggest that not only would this liven up your diet, but it might also lower risk of developing...
Parkinson's patients who take medications that block muscarinic cholinergic receptors have increased amyloid plaque and neurofibrillary tangle pathology, according to an article by Elaine Perry of the Newcastle General...
In the July 8 issue of Current Biology, researchers at the University of California, Los Angeles, and Kyoto University, Japan, reveal that mice carrying a mutated version of the Notch gene suffer from spatial learning and memory defects...
It’s getting hot around calcium. A trend is afoot about something going awry with calcium regulation in Alzheimer neurons, and it makes this ion an increasingly attractive suspect in AD pathogenesis, even if important details remain murky...
Some foods only reveal their flavor after you add a dash of salt. Similarly, say the authors of an article in the July 18 issue of Science, some genes only show an association with disease when environmental factors are taken into account...
PET Diagnosis Poised for Prime Time? FDA Wants Consensus, Better Trials ApoE Catalyst Conference Explores Drug Development Opportunities Institute for the Study of Aging Symposium
The proteasome, that large subcellular grinder that recycles protein, plays a major role in localized degeneration of axons, according to a report in this week's Neuron. Such neuronal damage typically follows traumatic injury, but it can also be caused by...
On May 29 and 30, the New York City-based <a href="http://www.aging-institute.org/venture.htm">Institute for the Study of Aging</a> convened a small symposium to take the pulse of current research on ApoE, the leading risk factor for nonfamilial AD...
In this week’s Neuron, researchers report that polyglutamine-expanded huntingtin (Htt)—the direct cause of Huntington's disease—exacerbates inositol triphosphate-mediated calcium signaling...
Human tau—whether normal or a disease-causing mutant—does not make for a healthy <em>C. elegans</em>. In the Early Edition of PNAS, Gerry Schellenberg and colleagues report that both types of transgenic tau lead to behavioral, synaptic, and pathologic abnormalities in the worms...
Tao et al. and Honbou et al. recently reported the crystal structure of DJ-1 at resolutions of 1.8 and 1.95 Ångstroms, respectively (see <a href="/news/research-news/spotlight-dj-crystal-structure-solved-parkinsons-protein">ARF related news story</a>), but the latest report by Greg Petsko and colleagues in the July 10 PNAS Early Edition online, tops that by almost another Ångstrom.
A report in this week's PNAS suggests that neurogenesis can occur in response to neurodegeneration in human brains. Principal author Richard Faull and colleagues at the University of Auckland, New Zealand, report that significantly more neuronal proliferation occurs...
Recent evidence has enhanced the image of astrocytes, suggesting these glial cells are a source for stem cells, and that they mop up Aβ. But online publications in this week's PNAS and Nature Neuroscience indicate that astrocytes also are a major impediment to...
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