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Papers in tomorrow’s Cell and last week's Neuron reveal that protein phosphorylation plays a key role in spinocerebellar ataxia type 1 (SCA-1), an ultimately fatal neurodegenerative disease marked by progressive loss of muscle control...
A paper in yesterday’s online Nature Medicine suggests that the involuntary movements that accompany standard treatment for Parkinson's disease may be controlled by administration of neurotransmitter analogs...
A report in next week's PNAS adds to the growing evidence that insulin-degrading enzyme (IDE), or insulysin, plays a role in the degradation of amyloid-β (Aβ)...
On May 4-5, Harvard Medical School briefed reporters on new directions in biomedical research. The meeting featured diverse presentations ranging from basic research on RNA splicing and clinical trials of proteasome inhibitors to the evolutionary role of genes involved in intelligence and mental retardation, and more...
Successful radiotracers for positron emission tomography (PET) diagnosis of AD are a mere year or two away, according to leading researchers who met on May 1-2 in New York...
In today's Science, researchers report that mutations in the protein dynein—the motor that drives the transport of large molecules from the synaptic terminal back to the neuron’s cell body—can lead to forms of neurodegeneration reminiscent of motor neuron diseases such as amyotrophic lateral sclerosis (ALS)...
Neuronal progenitors are faced with many forks on the road to becoming one of more than 1,000 different neurons found in the human central nervous system...
Counterintuitive as it may seem, in tomorrow's Science researchers report that the inhibitory neurotransmitter ã-aminobutyric acid (GABA) can temporarily restore age-related losses of visual acuity in monkeys...
In this week's Journal of the American Medical Association, researchers report a correlation between Alzheimer's disease (AD) and the appearance in the cerebrospinal fluid (CSF) of two proteins thought to play major roles in the progression of the disease—amyloid β42 (Aβ42) and tau...
Several anticholesterol drugs, particularly statins, at standard doses can significantly reduce plasma levels of the brain cholesterol degradation product 24S-hydrocholesterol, according to a report in this week's Archives of Neurology...
Massimo Tabaton of the University of Genoa, Italy, has been awarded this year's Alzheimer's Medal, presented annually by the associate editors of the Journal of Alzheimer's Disease "for the best article published in the previous year's volume."...
There is growing interest in the overlap among Alzheimer's disease, Parkinson's disease, and less common synucleinopathies and tauopathies that can share features of both diseases...
Like good cholesterol and bad cholesterol, the Alzheimer's community has realized that there may also be good Aβ and bad Aβ...
Stem cells injected into the cerebral ventricles—or even injected intravenously—find their way to sites of inflammation in an animal model of multiple sclerosis (MS), according to a report in today’s Nature...
What happens when the protein machinery that drives the cell division cycle gets activated in non-dividing cells such as neurons? The cells will most likely die. Recent evidence suggests that just this type of scenario plays out in the brains of Alzheimer's patients...
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