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How do Schwann cells know how much myelin to wrap around an axon during development? It's not a trivial problem—a small difference in myelin thickness can change signal transduction speed through the axon, with potentially devastating consequences...
Studying the similarities between humans and mice is easy. Studying the differences can be almost impossible. Take the cerebral cortex...
As part of the tangled web of pathology that leads to Alzheimer’s disease, inflammation is associated with local immune responses. For example, recent data indicate that both AD patients and elderly healthy people have...
A loss of activity in areas of the brain that typically fire up when our brains are at rest may prove to be an accurate diagnostic marker for the earliest stages of Alzheimer's disease...
It can be a template, a receptor, an enzyme, or metabolic regulator. But can it be all of these at one time? The answer seems to be yes...
If researchers are correct, ozone may precipitate formation of the plaques found in the brains of Alzheimer's patients...
Gabrielle Strobel Interviews Sheldon Goldberg
A multi-institutional collaboration has vaccinated rhesus monkeys (<em>Macaca mulatta</em>) against the Aβ peptide in an effort to establish a more human-like animal model than mice for use in vaccination studies...
Researchers who follow the ups and downs of protein expression in Alzheimer’s disease (AD) may well think they are being taken on a roller coaster ride. Early on, many proteins are...
A report in press in the Journal of Biological Chemistry, published online February 24, adds to the growing body of evidence that traces the etiology of Parkinson's disease to the mitochondria...
The Alzheimer Research Forum congratulates three esteemed scientists, and occasional contributors to this website, on the awards they won this past week...
Gabrielle Strobel Interviews William A. Haseltine
In the current Archives of General Psychiatry, researchers compile an overview of the known genetic components of major brain diseases and then apportion the cost to society accordingly. AD comes out...
In this week’s PNAS, researchers report that brain-derived neurotrophic factor (BDNF) protects newborn neurons in songbirds. BDNF has also been linked to...
The triplet repeat disease X-linked spinal and bulbar muscular atrophy (SBMA) is caused by a polyglutamine expansion in the androgen receptor (AR) gene. Just how this expansion causes degeneration of lower motor neurons...
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