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Elderly men with symptoms of ataxia and intention tremor may actually have a disorder related to fragile X syndrome, a common form of mental retardation in children. These men show signs of...
Alzheimer's researchers sneak regular peeks over the shoulders of colleagues working on Parkinson's and other neurodegenerative diseases. Why not do the same with schizophrenia researchers, who are working in a disease that features...
Which is more dangerous, the cellular (PrPc) or the infectious (PrPSc) prion protein? Until recently, this would have been easy to answer. But evidence is growing that...
A nifty instrument for mapping the 3-D shape of macromolecular surfaces, the atomic force microscope (AFM) over the last five years has become an established method of measuring how environmental conditions affect Aβ fibril formation as well as...
Cholesterol and lipoproteins, particularly ApoE, are two known risk factors for idiopathic Alzheimer’s disease. But despite numerous reports, scientists’ understanding of how they influence the disease process remains vague...
While it is generally accepted that PS1 has eight transmembrane domains (8-TM), a paper in this week’s early online PNAS resurrects the hypothesis that PS1 assumes a 7-TM topology, and suggests it may have a role...
Combining memantine with an older, widely used AD drug further improves measures of cognition, global well-being, activities of daily living, and behavior in people with moderate to severe AD, according to a study published in the January 21 JAMA...
What if all it took was a little sugar—not to make some other medicine go down, but as a therapy in itself for Huntington's disease? This is the promise of an article published...
For several years now, the Alzheimer's research and treatment communities have been awaiting the fruition of promising research into quantitative imaging agents that could signal the presence of amyloid...
Anyone interested in studying aging cells may want to check out today's Nature Genetics, which reports a transcriptome profiling method that identifies age-related patterns in gene expression across different species...
A paper in press in the Journal of Biological Chemistry suggests that sphingolipids, in addition to cholesterol, may play an important role in regulating intramembrane cleavage of amyloid β precursor protein...
This report summarizes some of the genetic findings for late-onset Alzheimer's disease presented last November at the 33rd Annual Meeting of the Society for Neuroscience in New Orleans...
In the current issue of Science, researchers report that CREST—a protein that interacts with CREB (cAMP response element-binding protein) binding protein, or CBP—is required for proper dendritic growth in neurons...
In yesterday’s Neuron, researchers presented fresh in-vivo support for the amyloid hypothesis and bolster the status of the APP protease BACE as the current favorite target for AD therapy development...
Genome, transcriptome, proteome, and now we have the interactome, the full complement of protein-protein interactions that can occur in the cell...
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