Pittsburgh Compound-B Zooms into View
For several years now, the Alzheimer's research and treatment communities have been awaiting the fruition of promising research into quantitative imaging agents that could signal the presence of amyloid...
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Wholesale Protein Changes with Age
Anyone interested in studying aging cells may want to check out today's Nature Genetics, which reports a transcriptome profiling method that identifies age-related patterns in gene expression across different species...
In Lipid Raft, Sphingolipids Affect AβPP Processing
A paper in press in the Journal of Biological Chemistry suggests that sphingolipids, in addition to cholesterol, may play an important role in regulating intramembrane cleavage of amyloid β precursor protein...
New Orleans: Rudy Tanzi on What’s Brewing in AD Genetics
This report summarizes some of the genetic findings for late-onset Alzheimer's disease presented last November at the 33rd Annual Meeting of the Society for Neuroscience in New Orleans...
CREST—Not Just for Teeth Anymore, but Neurons, Too
In the current issue of Science, researchers report that CREST—a protein that interacts with CREB (cAMP response element-binding protein) binding protein, or CBP—is required for proper dendritic growth in neurons...
Target BACE: Better Than Ever?
In yesterday’s Neuron, researchers presented fresh in-vivo support for the amyloid hypothesis and bolster the status of the APP protease BACE as the current favorite target for AD therapy development...
Mapping Protein Networks in the Roundworm
Genome, transcriptome, proteome, and now we have the interactome, the full complement of protein-protein interactions that can occur in the cell...
Pilot Study Suggests Clioquinol Benefits AD Patients
Results are in from the first pilot study to test the potential benefit of clioquinol in Alzheimer's disease patients, suggesting that the drug improves cognition and lowers plasma levels of Aβ42 in some patients...
A Better Tau Trap? Viral Somatic Transfer of Mutant Tau in Rats
Localized gene transfer has produced the first rat model of neurofibrillary tangles, announce the authors of a report in the January 2004 American Journal of Pathology...
Antiinflammatory Drugs Protect Hippocampal Neurogenesis
Two recent studies confirm that local inflammation inhibits adult neurogenesis in the hippocampus and, in a promising advance, they find evidence that...
Prions, the Mark of Memory Formation?
As government officials scramble to contain the current scare over a cow that tested positive for BSE in Washington state earlier this week, researchers in New York and Boston report...
More on TGF-β—Can It Protect against AD?
A report in last week's Cell suggests that TGF-β1, one of the three mammalian isoforms of that growth factor, can protect against excitotoxic neurodegeneration...
Can’t Close Spigot? Try Opening Drain: New Tack on Amyloid Degradation
Scientists prospecting the amyloid hypothesis for new treatment strategies have set their sights on the idea of boosting the enzymatic destruction of the Aβ peptide...
Swedish Twins Suggest Environment Trumps Genes In Late-Onset AD
A study of Swedish twins, including many over the age of 80, leads researchers to conclude that the genetic contribution to late-onset Alzheimer's disease is not as great as previously estimated...
"Insight" into Protein Folding
Protein folding aficionados may well want to hold on to their December 18/25 copy of Nature, which devotes a special insight section to the topic...
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