Follow the Leader to Higher BACE Levels
As drug discovery in AD research is shifting from inhibiting the γ-secretase to inhibiting the β-secretase (BACE), interest in the entire life cycle of BACE has grown, concomitantly...
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Schizophrenia Drugs Said to Raise Stroke Risk in Dementia Patients
The Reuters news agency reported today that Eli Lilly and Co. has notified doctors of a significant increase in the risk for stroke and death that it has observed in demented elderly patients...
AβPP Ligand Found? Neurons Respond to F-Spondin
Amyloid-β precursor protein (AβPP) has gained a notorious reputation because it releases the Aβ peptide that gums up intraneuronal spaces in Alzheimer's brains. Like many of notoriety, however, AβPP probably has a good side...
ATM Links DNA Damage to Neuronal Cell Cycle Activation and Apoptosis
In today’s Neuron, researchers report that ATM, or ataxia-telangiectasia mutated protein, mediates cell cycle activation and subsequent death of neurons in response to DNA damage...
Fats, Aβ, Oxidative Stress: Feeding Forward and Backward, Killing Neurons?
Add a new strand to the growing web of relationships among production of the Aβ peptide, regulation of cholesterol and other lipids, oxidative stress, and the death of neurons in Alzheimer's. Researchers believe that Aβ drives an increase in the conversion of...
A Growing Portfolio: CDK5 Implicated in Parkinson’s, Too
Cyclin-dependent kinase 5 (CDK5) is a protein that regulates postsynaptic dopamine signaling by phosphorylating the postsynaptic protein DARPP-32, and subsequently inhibiting protein kinase A (PKA). When it comes to neurodegeneration...
Nitric Oxide and Zinc—Conspirators in Cell Death
Who would have thought that nitric oxide (NO) and zinc (Zn+) act in concert to activate apoptosis? That's the conclusion Stuart Lipton and colleagues propose in a report in the February 5 Neuron...
Not Quite a Dolly, But It's a Human Clone
Researchers in South Korea have apparently cloned the first human embryo. Perhaps equally significant, they have also extracted pluripotent stem cells from the embryo at the blastocyst stage...
New Microarray Data Offer Grist for AD Hypothesizing Mills
Check out the newest gene microarray results in the Alzheimer's brain, and see if they give a lift to some of our favorite hypotheses and molecular suspects...
Lost in Translation: Memories Need MAP to Find Their Way Home
The quest to unveil the mystery of memory and synaptic plasticity—for some years the domain of behavioral biologists and electrophysiologists—has led scientists squarely back to basic molecular biology...
Alternative Splicing May Make Cells Unique
In this month’s Nature Genetics, MIT researchers suggest that each of the billions of neurons in the human brain may also have its own unique address—courtesy of alternative splicing...
Exchange of Letters Asks if Silver Lining in Vaccine Trial Was Real
One bit of reassuring evidence tempered the dismay over the encephalitis cases that ended dosing in the phase 2 trial of an Aβ vaccine: At least the vaccine removed the plaques. Not so fast...
Newfangled Genome Maps May Guide the Hunt for Disease Genes
Two papers in tomorrow's Science describe genetic maps that may prove useful for studying the genetic basis for human disease...
Agonist of PPARγ Cousin PPARδ Flags Cancer Caution
Activation of PPARγ's cousin PPARδ may spur the development of intestinal cancers in mice, according to a report in the February Nature Medicine...
Could Alzheimer’s Drugs Mean “Good Night” to Good Memory?
If you want to make sure to remember something, sleep on it. Sleep research confirms this adage, and indeed, its chemical underpinnings may have surprising implications for Alzheimer’s disease treatment...
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