Multitalent RNA: Guides Stem Cells, Cuts Itself to Turn Off Gene
It can be a template, a receptor, an enzyme, or metabolic regulator. But can it be all of these at one time? The answer seems to be yes...
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"Ozone Holes" in Human Brain? New Twists on Protein Folding
If researchers are correct, ozone may precipitate formation of the plaques found in the brains of Alzheimer's patients...
Gabrielle Strobel Interviews Sheldon Goldberg
Gabrielle Strobel Interviews Sheldon Goldberg
Primate Model Promising for Studying Aβ Vaccine
A multi-institutional collaboration has vaccinated rhesus monkeys (<em>Macaca mulatta</em>) against the Aβ peptide in an effort to establish a more human-like animal model than mice for use in vaccination studies...
Dying to Bind: DENN/MADD Promotes Neuron Death in AD Brain
Researchers who follow the ups and downs of protein expression in Alzheimer’s disease (AD) may well think they are being taken on a roller coaster ride. Early on, many proteins are...
Loss of Parkin in Mammals Takes Steam Out of Mitochondria
A report in press in the Journal of Biological Chemistry, published online February 24, adds to the growing body of evidence that traces the etiology of Parkinson's disease to the mitochondria...
A Virtual Toast to Thal, Nitsch, and Stanley on Their Awards
The Alzheimer Research Forum congratulates three esteemed scientists, and occasional contributors to this website, on the awards they won this past week...
Gabrielle Strobel Interviews William A. Haseltine
Gabrielle Strobel Interviews William A. Haseltine
Brain Disorders: Tallying a Costly Mix of Mendel, Complex Genetics, and Environment
In the current Archives of General Psychiatry, researchers compile an overview of the known genetic components of major brain diseases and then apportion the cost to society accordingly. AD comes out...
A Little BDNF May Help Your Canary Sing
In this week’s PNAS, researchers report that brain-derived neurotrophic factor (BDNF) protects newborn neurons in songbirds. BDNF has also been linked to...
Better Model Links Polyglutamine Disease to Growth Factor VEGF
The triplet repeat disease X-linked spinal and bulbar muscular atrophy (SBMA) is caused by a polyglutamine expansion in the androgen receptor (AR) gene. Just how this expansion causes degeneration of lower motor neurons...
MARK Homologue Sparks Tau Terror in Fruit Fly
PAR-1, a homologue of microtubule-affinity regulating kinase (MARK), kicks off the phosphorylation events that culminate in cell death in a fly model of tauopathy, according to...
ALS—An RNA Editing Disease?
In the February 26 Nature, researchers report that failure of the RNA editor is linked to amyotrophic lateral sclerosis (ALS)...
Follow the BACE to Higher Aβ Levels
Where there is more BACE, there is more Aβ. Researchers show that increased BACE expression and activity correlate with increased Aβ production in the frontal cortex of AD patients...
Amyloidoses—Native and Synthetic Fibril Formers Offer Clues
Amyloidoses are a varied and complex set of syndromes caused by aggregation of specific proteins such as the amyloid-β, found in the brains of Alzheimer's patients, and...
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