St. Moritz, Part 1: Science Flourishes in High-Altitude Air
In the waning days of March, researchers from around the world met in St. Moritz to send off the cold season with three days of science...
ALL NEWS
6538 RESULTS
Sort By:
- Most Recent
- Most Commented
St. Moritz, Part 2. Not Just AD: Oligomers Haunt Prion Researchers, Too
This story is a continuation of the St. Moritz series started on Monday, 24 May 2004...
Get Out the Rulers—Stunted Dendrites May Flag Early Alzheimer's
Stunted dendritic arbors in a subpopulation of hippocampal granule cells are an early sign of Aβ-induced damage, according to a new study of transgenic PDAPP mice...
Sniffer Snuffs Out Stress, or Does Aging Boil Down to Oxidation?
Evidence linking mitochondrial oxidative stress with neurodegeneration has been pouring forth lately. But news of novel mechanisms...
GLOing Reports from Gene Profiling of Mouse Models
Despite the vastly heterogeneous nature of mammalian brains, researchers are pressing on with gene profiling experiments aimed at...
NGF—From Crystal Structure to Human Trials
Last week, both ends of the nerve growth factor (NGF) research spectrum advanced by a step. On its fundamental science, an article in Science describes...
Anticoagulants for Alzheimer’s?
If aggregates of the sticky amyloid-β can contribute to the pathology of Alzheimer’s disease (AD), then maybe unsticking them will help reverse the process...
Transdifferentiation—Alive Again?
May 1 2004. Cells of the blood lineage, introduced into patients receiving bone marrow transplants, are reported to have given rise to brain cells. The finding reawakens hope that stem cells from diverse organs may one day be used to repair damage in other types of tissue...
NO Parkin—A Simple Modification Arrests Ligase
The clamp, the boot, whatever you call it, if you find one on your car you’ll appreciate how a seemingly small attachment can keep its wheels from turning. In today’s Sciencexpress, researchers report that covalently clamping parkin with nitric oxide...
"Meet You on the Raft!"—Aβ Rallying Cry?
Do solitary Aβ peptides begin their journey toward insoluble plaques by meeting up with partners on lipid rafts in the plasma membrane? Researchers report evidence that, in an APP-transgenic mouse model, Aβ dimerizes in the rafts and, what's more...
Spinal Tap Dance—Do Myelin-Reactive T cells Protect or Destroy?
Priming the immune system to recognize and clear endogenous antigens from the nervous system has always been a controversial therapeutic strategy. We only have to look to...
ABAD, aka ERAB: Mitochondrial Miscreant Returns
The Aβ-binding alcohol dehydrogenase (ABAD) forms a complex with Aβ in mitochondria, promoting leakage of free radicals, mitochondrial dysfunction, and cell death...
ALS—Bridging the Way to Therapy
Designed to speed transport and communication, bridges may also be useful for slowing disease. Researchers suggest as much in their review of one promising strategy for slowing the progression of ALS...
Dora Kovacs Reports from IBC Conference in San Diego
Last month, the commercial conference planner IBC Screentech held a conference on drug development approaches in neurodegeneration in San Diego, California, as part of its World Summit series...
Pink Mutations Link Parkinson’s Disease to Mitochondria
Mutations in Pink1, a gene coding for a mitochondrial protein kinase, has just been fingered as a genetic cause for parkinsonism. In today’s Sciencexpress, researchers report that Pink1 and PARK6, a long-sought-after genetic locus that is linked with early-onset Parkinson’s disease, are...
Current Filters
No filters selected