Protein Misfolding, Amyloid and Conformational Disease
High Ground for Protein Folding: Erene Mina Reports from Snowmass, Elevation 8,223 Protein Misfolding, Amyloid and Conformational Disease
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Aβ Production Linked to Oxidative Stress
Oxidative stress has been postulated as a major factor in the pathology of a variety of neurodegenerative disorders, including Alzheimer’s disease (AD). However, evidence linking this type of stress to...
Protection Against Parkinson’s—How the DJ Changes Station
Mutations in the gene for the protein DJ-1 are known to cause early-onset Parkinson’s disease. Exactly what DJ-1 does is unknown, however, so how...
Nogo’s Scope Broadens to Include Multiple Sclerosis
The Nogo protein, notorious for its ability to sabotage nerve regeneration, appears to also promote the neurodegeneration seen in multiple sclerosis, at least in...
Viral VEGF Treats Mouse ALS
Currently, there are no cures for amyotrophic lateral sclerosis (ALS), the late-onset neurodegenerative disease that claims most victims...
Poor Proofreading May Shorten Your Lifespan
Despite the efforts of a league of DNA proofreading and copyediting enzymes, the genetic code that keeps us all alive is not impervious to mutation...
Neurogenesis—A Mechanism for Memory Storage, Clearance?
Research presented in the May 27 issue of Neuron supports links between ongoing excitatory activity in the neural networks of the hippocampus and adult neurogenesis...
How to Turn a Peroxidase into a Chaperone—Just Add Stress
Chaperones and redox enzymes, such as peroxidases, play major roles in keeping eukaryotic cells free from the ravages of reactive oxygen species...
International Winter Meeting: Growth and Death in the Nervous System
St. Moritz, Part 1: Science Flourishes in High-Altitude Air St. Moritz, Part 2. Not Just AD: Oligomers Haunt Prion Researchers, Too St. Moritz: Part 3. This Research Isn't Folding Up: Genetics, Transport, Seeding, Protein Microscopy St. Moritz, Part
St. Moritz: Part 5. Vaccine, Microglia, NGF News Fill in Neuroimmunology Picture
This story is a continuation of the St. Moritz series started on Monday, 24 May 2004...
St. Moritz: Part 3. This Research Isn't Folding Up: Genetics, Transport, Seeding, Protein Microscopy
This story is a continuation of the St. Moritz series started on Monday, 24 May 2004...
St. Moritz, Part 4. (It) Take(s) Five (To Make Aβ), New BACE Mice
This story is a continuation of the St. Moritz series started on Monday, 24 May 2004...
Aggregation Alchemy: Dobson Reviews Therapeutic Approaches
For those who’d like to brush up on their knowledge of protein aggregation diseases, Chris Dobson of the University of Cambridge offers a quick tutorial in tomorrow’s Science...
α-Secretase Returns to Center Stage
The AD community’s overwhelming focus on β and γ-secretase has all but obscured a third enzyme that clips APP in an alternative...
Eat 'Em Up Early—Autophagy Might Delay Huntington's Disease
Early in the Huntington's disease (HD) process, before mutant huntingtin protein forms aggregates, there may be an opportunity to delay the disease...
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