Philadelphia: Mom Was Right. Eat Your Carrots!
At the Philadelphia conference, Francine Grodstein presented data demonstrating that taking β-carotene starting in late mid-life protects...
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Philadelphia: All Is Not Well with the Statin Story
One of the field’s biggest hopes for a quick and easy new AD therapy received a punch in the stomach today...
Familial Alzheimer's Presenilin Gene Perturbs Neurogenesis?
Mutations in presenilin could contribute to the memory loss of Alzheimer's disease by perturbing hippocampal neurogenesis...
Microglia Aid and Abet Aβ Toxicity and Clearance
How is the peptide Aβ toxic to neurons? In the July 7 Journal of Neuroscience, researchers offer this clue...
Stroke Recovery—No Go with Nogo?
Researchers have realized over the last decade or so that stroke and Alzheimer’s disease (AD) have some things in common...
Motoneuron Mitochondria: Preferred Destination For Mutant SOD1
Two articles in the July 8 issue of Neuron may provide a leap forward in understanding how mutations in copper-zinc superoxide dismutase (SOD1) lead to...
Gabrielle Strobel Interviews Martin Citron
Gabrielle Strobel Interviews Martin Citron
Huntingtin, BDNF, Neurodegeneration: Is Speed of the Essence?
In today's Cell, researchers report that huntingtin (htt) enhances transport of brain-derived neurotrophic factor (BDNF) along microtubules...
Promoter Bashing—Mitochondrial Ones Damaged in AD Brain
Recently, scientists reported that certain human promoter sequences are more susceptible to age-related mutagenesis, suggesting that...
High Ground for Protein Folding: Erene Mina Reports from Snowmass, Elevation 8,223
Gathering in Colorado’s Rocky Mountains, scientists from around the world discussed their independent research developments, only to realize that they have more in common than previously imagined...
Cholinesterase Inhibitors Not What They're Cracked Up To Be?
The results of the AD2000 study of donepezil (Aricept) in Alzheimer's—published in the June 26 Lancet—made a big splash in the media pond. While confirming previous...
The Lactic Acid Shuttle—It May Change How We Image the Brain
In today’s Science, researchers at Cornell University provide compelling evidence that neurons preferentially use lactate as a source of energy...
Downer for GDNF Trial: No Clinical Improvement
BioWorld Online yesterday reported that a phase 2 trial of the neurotrophic factor GDNF...
For Better Memory, Try Keeping Your HAT On…
In yesterday’s Neuron, two independent laboratories report that the Histone Acetyl Transferase (HAT) activity of CREB-binding protein (CBP) is crucial for learning and memory...
Soft Background Noise Said to Keep Wheels Greased for Memory
Low-level, ongoing excitatory neurotransmission at synapses—so-called "minis"—keep the postsynaptic cell ready for rapid remodeling by capping local protein translation...
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