Chromosome 5 Is in the Bag
In the September 16 issue of Nature, another legion of geneticists, this one led by Jeremy Schmutz of the Stanford Human Genome Centre in California, pulls the curtain back on a chromosome: number 5...
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Focus on Aβ Fibrils: Targeting β-sheets and Foiling Them
Two papers from the past week take aim at the β-sheet structure of proteins prone to pathological aggregation...
Move Over, Mitochondria—Make Room for ER-Induced Cell Death
Mitochondria are a major source of the reactive oxygen species (ROS) that may play a role in neurodegeneration. Now evidence suggests that ROS generated in the endoplasmic reticulum may also lead to cell death...
Want Plaque Protection? Try the X Factors…
…X11, that is, a nuclear adaptor protein that binds to the intracellular domain of amyloid-β precursor protein (AβPP)...
Can Sonic Hedgehog Rejuvenate Parkinson Disease Neurons?
A study in the September issue of Molecular Therapy reports that the developmental regulatory factors Sonic hedgehog (Shh) and Gli-1, but not Nurr-1, can protect dopaminergic neurons...
Fish Oil Swims Ahead in Dietary Brain Protection Race
Organism-level experimental data now lend some support to the epidemiologic evidence that the fatty acids in fish oil can protect against Alzheimer disease...
Neurons Found Marching to the Beat of the Glial Drum
A new study suggests that neurotransmitters from astrocytes can induce synchronous electrical currents in hippocampal neurons…
Increased Neurogenesis in AD? Evidence from APP Mice Strengthens Case
An article in PNAS reports evidence of increased neurogenesis in an animal model of Alzheimer disease that supports results obtained from humans...
Staring into the Eyes of Death—Measuring Apoptosis One Neuron at a Time
By looking into the mammalian eye with a sophisticated microscope, researchers see and track apoptosis in single neurons…
Gingko Goes on Trial Again…This Time in London
Researchers will now attempt to put the dietary supplement gingko biloba to a rigorous scientific test in the earliest stages of AD…
Lysosomes and Proteasomes Compete for PD Researchers' Attention
Look to the lysosome—not the proteasome—for protein degradation gone awry in Parkinson's disease, suggest the authors of an article published in this week’s Science...
Poor Vision Illuminates Zinc-Mediated Protein Misfolding
Protein misfolding and aggregation link Alzheimer's disease with familiar neurodegenerative disorders such as prion disorders or Parkinson's disease, but also some further afield...
γ-Secretase Activity is Mostly Intracellular—Needs PEN-2 C-terminus
A troika of papers provides evidence that γ-secretase is primarily localized intracellularly and needs the C-terminus of PEN-2 for complete integration...
Caught in the Act: NPC1 Found to Bind Cholesterol
Neiman-Pick type C (NPC) disease intrigues Alzheimer's researchers for several reasons. For one thing, the neurodegenerative disorder involves...
Memory Loss—Really Lost or Just Forgotten—New Test Decides
A new type of water maze test can distinguish memory storage from memory retrieval problems in rats...
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